Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period
Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic enc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Brain Sciences |
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| Online Access: | http://www.mdpi.com/2076-3425/8/6/101 |
| _version_ | 1819120359927971840 |
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| author | Clémence Disdier Xiaodi Chen Jeong-Eun Kim Steven W. Threlkeld Barbara S. Stonestreet |
| author_facet | Clémence Disdier Xiaodi Chen Jeong-Eun Kim Steven W. Threlkeld Barbara S. Stonestreet |
| author_sort | Clémence Disdier |
| collection | DOAJ |
| description | Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic encephalopathy in full term infants. Therefore, there is an urgent need for adjunctive therapeutic strategies. Post-ischemic neuro-inflammation is a crucial contributor to the evolution of brain injury in neonates and constitutes a promising therapeutic target. Recently, we demonstrated encouraging neuroprotective capacities of anti-cytokine monoclonal antibodies (mAbs) in an ischemic-reperfusion (I/R) model of brain injury in the ovine fetus. The purpose of this review is to summarize the current knowledge regarding the inflammatory response in the perinatal sheep brain after I/R injury and to review our recent findings regarding the beneficial effects of treatment with anti-cytokine mAbs. |
| first_indexed | 2024-12-22T06:19:25Z |
| format | Article |
| id | doaj.art-246aa4d8ad784fb8995656c9b152cab0 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-22T06:19:25Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-246aa4d8ad784fb8995656c9b152cab02022-12-21T18:36:00ZengMDPI AGBrain Sciences2076-34252018-06-018610110.3390/brainsci8060101brainsci8060101Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal PeriodClémence Disdier0Xiaodi Chen1Jeong-Eun Kim2Steven W. Threlkeld3Barbara S. Stonestreet4Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Neuroscience, Regis College, Weston, MA 02493, USADepartment of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI 02905, USAPerinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic encephalopathy in full term infants. Therefore, there is an urgent need for adjunctive therapeutic strategies. Post-ischemic neuro-inflammation is a crucial contributor to the evolution of brain injury in neonates and constitutes a promising therapeutic target. Recently, we demonstrated encouraging neuroprotective capacities of anti-cytokine monoclonal antibodies (mAbs) in an ischemic-reperfusion (I/R) model of brain injury in the ovine fetus. The purpose of this review is to summarize the current knowledge regarding the inflammatory response in the perinatal sheep brain after I/R injury and to review our recent findings regarding the beneficial effects of treatment with anti-cytokine mAbs.http://www.mdpi.com/2076-3425/8/6/101braincytokinesischemia reperfusionneuro-inflammationovine fetusmonoclonal antibodies |
| spellingShingle | Clémence Disdier Xiaodi Chen Jeong-Eun Kim Steven W. Threlkeld Barbara S. Stonestreet Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period Brain Sciences brain cytokines ischemia reperfusion neuro-inflammation ovine fetus monoclonal antibodies |
| title | Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period |
| title_full | Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period |
| title_fullStr | Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period |
| title_full_unstemmed | Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period |
| title_short | Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period |
| title_sort | anti cytokine therapy to attenuate ischemic reperfusion associated brain injury in the perinatal period |
| topic | brain cytokines ischemia reperfusion neuro-inflammation ovine fetus monoclonal antibodies |
| url | http://www.mdpi.com/2076-3425/8/6/101 |
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