Comparison of Efficacy and Safety of Intramuscular Piroxicam and Tramadol for Post-operative Pain in Patients Undergoing Caesarean Delivery
Introduction: Post-caesarean section pain can be both stressful and unfavourable. Effective and rapid reduction of pain facilitates early ambulation and care of the new born. NonSteroidal Anti-Inflammatory Drugs (NSAIDs) and opioids are used for pain relief but they are associated with adverse ef...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8785/21861_CE[Ra]_F(Sh)_PF1(PI_RK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Post-caesarean section pain can be both
stressful and unfavourable. Effective and rapid reduction of
pain facilitates early ambulation and care of the new born. NonSteroidal Anti-Inflammatory Drugs (NSAIDs) and opioids are
used for pain relief but they are associated with adverse effects
both in the mother and the child.
Aim: To evaluate efficacy and safety of piroxicam and tramadol
in post-caesarean section pain.
Materials and Methods: Primigravidae who underwent elective
caesarean section received either piroxicam 20mg or tramadol
100mg intra-muscularly, following recovery from anaesthesia.
Severity of pain was assessed using Visual Analogue Scale
(VAS) and side-effects to study drugs were noted. Rescue
analgesic butorphanol 2mg was administered if VAS score was
more than four. Patient’s satisfaction score was assessed at 12
hours post-operatively.
Results: Mean age in piroxicam and tramadol groups were
23.32±3.43 and 22.03±2.0 years respectively. Significant reduction in pain was observed at 2, 4, 8, 12 and 24 hours in both
groups (p<0.001). Pain relief was significant at 2, 4 and 8 hours
in piroxicam group compared to tramadol. Twenty-one and 12
patients in tramadol and piroxicam groups received rescue
analgesic respectively. Sedation and nausea was significantly
higher in tramadol group (p<0.001), 46.66% of patients graded
their satisfaction score as good and 15% as excellent in
piroxicam group.
Conclusion: Intra-muscular piroxicam was effective in reducing
post-caesarean section pain for 24 hours with minimal sideeffects compared to tramadol. |
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| ISSN: | 2249-782X 0973-709X |