Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges
Dogs with visceral leishmaniasis play a key role in the transmission cycle of <i>Leishmania infantum</i> to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/10/1565 |
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| author | Jaqueline Costa Leite Ana Alice Maia Gonçalves Diana Souza de Oliveira Lucilene Aparecida Resende Diego Fernandes Vilas Boas Helen Silva Ribeiro Diogo Fonseca Soares Pereira Augusto Ventura da Silva Reysla Maria da Silveira Mariano Pedro Campos Carvalhaes Reis Eiji Nakasone Nakasone João Carlos França-Silva Alexsandro Sobreira Galdino Paulo Ricardo de Oliveira Paes Marília Martins Melo Edelberto Santos Dias Miguel Angel Chávez-Fumagalli Denise da Silveira-Lemos Walderez Ornelas Dutra Rodolfo Cordeiro Giunchetti |
| author_facet | Jaqueline Costa Leite Ana Alice Maia Gonçalves Diana Souza de Oliveira Lucilene Aparecida Resende Diego Fernandes Vilas Boas Helen Silva Ribeiro Diogo Fonseca Soares Pereira Augusto Ventura da Silva Reysla Maria da Silveira Mariano Pedro Campos Carvalhaes Reis Eiji Nakasone Nakasone João Carlos França-Silva Alexsandro Sobreira Galdino Paulo Ricardo de Oliveira Paes Marília Martins Melo Edelberto Santos Dias Miguel Angel Chávez-Fumagalli Denise da Silveira-Lemos Walderez Ornelas Dutra Rodolfo Cordeiro Giunchetti |
| author_sort | Jaqueline Costa Leite |
| collection | DOAJ |
| description | Dogs with visceral leishmaniasis play a key role in the transmission cycle of <i>Leishmania infantum</i> to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec<sup>®</sup> and LetiFend<sup>®</sup>, have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies, such as the development of a transmission-blocking vaccines (TBVs) already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBV studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results, thus justifying the further development of this approach. |
| first_indexed | 2024-03-10T20:49:36Z |
| format | Article |
| id | doaj.art-246e2991f7244796a6f26978882c81de |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:49:36Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-246e2991f7244796a6f26978882c81de2023-11-19T18:24:38ZengMDPI AGVaccines2076-393X2023-10-011110156510.3390/vaccines11101565Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New ChallengesJaqueline Costa Leite0Ana Alice Maia Gonçalves1Diana Souza de Oliveira2Lucilene Aparecida Resende3Diego Fernandes Vilas Boas4Helen Silva Ribeiro5Diogo Fonseca Soares Pereira6Augusto Ventura da Silva7Reysla Maria da Silveira Mariano8Pedro Campos Carvalhaes Reis9Eiji Nakasone Nakasone10João Carlos França-Silva11Alexsandro Sobreira Galdino12Paulo Ricardo de Oliveira Paes13Marília Martins Melo14Edelberto Santos Dias15Miguel Angel Chávez-Fumagalli16Denise da Silveira-Lemos17Walderez Ornelas Dutra18Rodolfo Cordeiro Giunchetti19Laboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilMicroorganism Biotechnology Laboratory, Federal University of São João Del-Rei (UFSJ), Midwest Campus, Divinópolis 35501-296, MG, BrazilDepartment of Veterinary Clinic and Surgery, School of Veterinary, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilDepartment of Veterinary Clinic and Surgery, School of Veterinary, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilRené Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte 30190-002, MG, BrazilComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Arequipa 04000, PeruLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilLaboratory of Biology of Cell Interactions, Department of Morphology, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilDogs with visceral leishmaniasis play a key role in the transmission cycle of <i>Leishmania infantum</i> to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec<sup>®</sup> and LetiFend<sup>®</sup>, have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies, such as the development of a transmission-blocking vaccines (TBVs) already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBV studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results, thus justifying the further development of this approach.https://www.mdpi.com/2076-393X/11/10/1565canine visceral leishmaniasisvaccinestransmission-blocking vaccines |
| spellingShingle | Jaqueline Costa Leite Ana Alice Maia Gonçalves Diana Souza de Oliveira Lucilene Aparecida Resende Diego Fernandes Vilas Boas Helen Silva Ribeiro Diogo Fonseca Soares Pereira Augusto Ventura da Silva Reysla Maria da Silveira Mariano Pedro Campos Carvalhaes Reis Eiji Nakasone Nakasone João Carlos França-Silva Alexsandro Sobreira Galdino Paulo Ricardo de Oliveira Paes Marília Martins Melo Edelberto Santos Dias Miguel Angel Chávez-Fumagalli Denise da Silveira-Lemos Walderez Ornelas Dutra Rodolfo Cordeiro Giunchetti Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges Vaccines canine visceral leishmaniasis vaccines transmission-blocking vaccines |
| title | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
| title_full | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
| title_fullStr | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
| title_full_unstemmed | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
| title_short | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
| title_sort | transmission blocking vaccines for canine visceral leishmaniasis new progress and yet new challenges |
| topic | canine visceral leishmaniasis vaccines transmission-blocking vaccines |
| url | https://www.mdpi.com/2076-393X/11/10/1565 |
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