N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness

N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness

Abstract Despite the advent of precision medicine and immunotherapy, mortality due to lung cancer remains high. The sonic hedgehog (SHH) cascade and its key terminal factor, glioma-associated oncogene homolog 1 (GLI1), play a pivotal role in the stemness and drug resistance of lung cancer. Here, we...

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Main Authors: Hongliang Dong, Lili Zeng, Weiwei Chen, Qian Zhang, Fei Wang, Yan Wu, Bingjie Cui, Jingjing Qi, Xin Zhang, Cuilan Liu, Jiong Deng, Yong Yu, Clemens A. Schmitt, Jing Du
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01442-w

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