Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon
In Cameroon, a leading livestock production country, previous study highlighted the extensive misuse of veterinary drugs in the Far North Region, where we found the second cattle population of the country. Based on former work describing the presence of penicillin G (PEN) and oxytetracycline (OTC) r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2020.00478/full |
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| author | Ronald R. B. Vougat Ngom Ronald R. B. Vougat Ngom Harquin S. Foyet Rebecca Garabed André P. Zoli |
| author_facet | Ronald R. B. Vougat Ngom Ronald R. B. Vougat Ngom Harquin S. Foyet Rebecca Garabed André P. Zoli |
| author_sort | Ronald R. B. Vougat Ngom |
| collection | DOAJ |
| description | In Cameroon, a leading livestock production country, previous study highlighted the extensive misuse of veterinary drugs in the Far North Region, where we found the second cattle population of the country. Based on former work describing the presence of penicillin G (PEN) and oxytetracycline (OTC) residues in beef sold for human consumption in Maroua, the capital city of the Far North Region, this study was designed to determine the risk of PEN and OTC residue intake via beef consumption by the population of Maroua and to evaluate the consumer's knowledge on drug residues. Dietary exposure determined here was based on the average consumption of beef (found during a survey of 202 households randomly selected in Maroua) and the average concentration of the two antibiotic residues in beef (obtained after liquid chromatography–tandem mass spectrometry analysis of samples of liver and muscle collected from 202 cattle selected randomly in all the slaughterhouses of Maroua) found in our previous studies. The estimated daily intakes per capita of OTC and PEN residues from beef consumption were 22.81 and 2.37 μg, respectively. The risk was then assessed as high [9.6%; range from 6.4 to 15.4% of acceptable daily intake (ADI)] and considerable (2.2% range from 1.5 to 3.5% of ADI) for PEN and OTC residues, respectively. Based on the mean value, it can be concluded that the estimated risk of antibiotic daily intake through beef in Maroua is high (5.9% of ADI). Also, 98% of the surveyed population is not aware that meat can be contaminated by residues of veterinary drugs administered to slaughter animals. This ignorance would also increase the risk of contamination of the population of Maroua with antibiotic residues. This work clearly highlights the high risk of consuming beef by the population of Maroua. Taking into consideration the evidence of the intake of antibiotic residues from others sources, it is therefore very imperative that measures be taken by the government to ensure food safety in order to guarantee the health of the populations of this region in particular and Cameroon in general, hence the need for the establishment of a national food safety plan. |
| first_indexed | 2024-12-14T08:50:42Z |
| format | Article |
| id | doaj.art-246eea5d711241e1a58a4a403b10971a |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-14T08:50:42Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-246eea5d711241e1a58a4a403b10971a2022-12-21T23:09:03ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692020-08-01710.3389/fvets.2020.00478508938Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of CameroonRonald R. B. Vougat Ngom0Ronald R. B. Vougat Ngom1Harquin S. Foyet2Rebecca Garabed3André P. Zoli4National Advanced School of Engineering, University of Maroua, Maroua, CameroonZabit Laboratory of Agronomy and Geography, Maroua, CameroonDepartment of Biological Sciences, Faculty of Sciences, University of Maroua, Maroua, CameroonDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United StatesSchool of Veterinary Medicine and Sciences, University of Ngaoundéré, Ngaoundéré, CameroonIn Cameroon, a leading livestock production country, previous study highlighted the extensive misuse of veterinary drugs in the Far North Region, where we found the second cattle population of the country. Based on former work describing the presence of penicillin G (PEN) and oxytetracycline (OTC) residues in beef sold for human consumption in Maroua, the capital city of the Far North Region, this study was designed to determine the risk of PEN and OTC residue intake via beef consumption by the population of Maroua and to evaluate the consumer's knowledge on drug residues. Dietary exposure determined here was based on the average consumption of beef (found during a survey of 202 households randomly selected in Maroua) and the average concentration of the two antibiotic residues in beef (obtained after liquid chromatography–tandem mass spectrometry analysis of samples of liver and muscle collected from 202 cattle selected randomly in all the slaughterhouses of Maroua) found in our previous studies. The estimated daily intakes per capita of OTC and PEN residues from beef consumption were 22.81 and 2.37 μg, respectively. The risk was then assessed as high [9.6%; range from 6.4 to 15.4% of acceptable daily intake (ADI)] and considerable (2.2% range from 1.5 to 3.5% of ADI) for PEN and OTC residues, respectively. Based on the mean value, it can be concluded that the estimated risk of antibiotic daily intake through beef in Maroua is high (5.9% of ADI). Also, 98% of the surveyed population is not aware that meat can be contaminated by residues of veterinary drugs administered to slaughter animals. This ignorance would also increase the risk of contamination of the population of Maroua with antibiotic residues. This work clearly highlights the high risk of consuming beef by the population of Maroua. Taking into consideration the evidence of the intake of antibiotic residues from others sources, it is therefore very imperative that measures be taken by the government to ensure food safety in order to guarantee the health of the populations of this region in particular and Cameroon in general, hence the need for the establishment of a national food safety plan.https://www.frontiersin.org/article/10.3389/fvets.2020.00478/fulldietary intakepenicillin GoxytetracyclineCameroonrisk assessment |
| spellingShingle | Ronald R. B. Vougat Ngom Ronald R. B. Vougat Ngom Harquin S. Foyet Rebecca Garabed André P. Zoli Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon Frontiers in Veterinary Science dietary intake penicillin G oxytetracycline Cameroon risk assessment |
| title | Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon |
| title_full | Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon |
| title_fullStr | Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon |
| title_full_unstemmed | Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon |
| title_short | Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon |
| title_sort | human health risks related to penicillin g and oxytetracycline residues intake through beef consumption and consumer knowledge about drug residues in maroua far north of cameroon |
| topic | dietary intake penicillin G oxytetracycline Cameroon risk assessment |
| url | https://www.frontiersin.org/article/10.3389/fvets.2020.00478/full |
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