Bone Tissue and the Nervous System: What Do They Have in Common?
Degenerative diseases affecting bone tissues and the brain represent important problems with high socio-economic impact. Certain bone diseases, such as osteoporosis, are considered risk factors for the progression of neurological disorders. Often, patients with neurodegenerative diseases have bone f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/1/51 |
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| author | Arianna Minoia Luca Dalle Carbonare Jens Christian Schwamborn Silvia Bolognin Maria Teresa Valenti |
| author_facet | Arianna Minoia Luca Dalle Carbonare Jens Christian Schwamborn Silvia Bolognin Maria Teresa Valenti |
| author_sort | Arianna Minoia |
| collection | DOAJ |
| description | Degenerative diseases affecting bone tissues and the brain represent important problems with high socio-economic impact. Certain bone diseases, such as osteoporosis, are considered risk factors for the progression of neurological disorders. Often, patients with neurodegenerative diseases have bone fractures or reduced mobility linked to osteoarthritis. The bone is a dynamic tissue involved not only in movement but also in the maintenance of mineral metabolism. Bone is also associated with the generation of both hematopoietic stem cells (HSCs), and thus the generation of the immune system, and mesenchymal stem cells (MSCs). Bone marrow is a lymphoid organ and contains MSCs and HSCs, both of which are involved in brain health via the production of cytokines with endocrine functions. Hence, it seems clear that bone is involved in the regulation of the neuronal system and vice versa. This review summarizes the recent knowledge on the interactions between the nervous system and bone and highlights the importance of the interaction between nerve and bone cells. In addition, experimental models that study the interaction between nerve and skeletal cells are discussed, and innovative models are suggested to better evaluate the molecular interactions between these two cell types. |
| first_indexed | 2024-03-11T10:05:36Z |
| format | Article |
| id | doaj.art-246eff5676864068a9c75573a583dee2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T10:05:36Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-246eff5676864068a9c75573a583dee22023-11-16T15:05:24ZengMDPI AGCells2073-44092022-12-011215110.3390/cells12010051Bone Tissue and the Nervous System: What Do They Have in Common?Arianna Minoia0Luca Dalle Carbonare1Jens Christian Schwamborn2Silvia Bolognin3Maria Teresa Valenti4Department of Medicine, University of Verona, 37100 Verona, ItalyDepartment of Medicine, University of Verona, 37100 Verona, ItalyLuxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, 4365 Belvaux, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, 4365 Belvaux, LuxembourgDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, ItalyDegenerative diseases affecting bone tissues and the brain represent important problems with high socio-economic impact. Certain bone diseases, such as osteoporosis, are considered risk factors for the progression of neurological disorders. Often, patients with neurodegenerative diseases have bone fractures or reduced mobility linked to osteoarthritis. The bone is a dynamic tissue involved not only in movement but also in the maintenance of mineral metabolism. Bone is also associated with the generation of both hematopoietic stem cells (HSCs), and thus the generation of the immune system, and mesenchymal stem cells (MSCs). Bone marrow is a lymphoid organ and contains MSCs and HSCs, both of which are involved in brain health via the production of cytokines with endocrine functions. Hence, it seems clear that bone is involved in the regulation of the neuronal system and vice versa. This review summarizes the recent knowledge on the interactions between the nervous system and bone and highlights the importance of the interaction between nerve and bone cells. In addition, experimental models that study the interaction between nerve and skeletal cells are discussed, and innovative models are suggested to better evaluate the molecular interactions between these two cell types.https://www.mdpi.com/2073-4409/12/1/51stem cellsboneneurogenesisdifferentiation |
| spellingShingle | Arianna Minoia Luca Dalle Carbonare Jens Christian Schwamborn Silvia Bolognin Maria Teresa Valenti Bone Tissue and the Nervous System: What Do They Have in Common? Cells stem cells bone neurogenesis differentiation |
| title | Bone Tissue and the Nervous System: What Do They Have in Common? |
| title_full | Bone Tissue and the Nervous System: What Do They Have in Common? |
| title_fullStr | Bone Tissue and the Nervous System: What Do They Have in Common? |
| title_full_unstemmed | Bone Tissue and the Nervous System: What Do They Have in Common? |
| title_short | Bone Tissue and the Nervous System: What Do They Have in Common? |
| title_sort | bone tissue and the nervous system what do they have in common |
| topic | stem cells bone neurogenesis differentiation |
| url | https://www.mdpi.com/2073-4409/12/1/51 |
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