Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
Abstract Background Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. Aims We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify th...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11344-w |
| _version_ | 1797452290942042112 |
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| author | Fakhrddine Amri Chifaa Belkhayat Asmae yeznasni Hajar Koulali Rachid Jabi Abdelkrim Zazour Naima Abda Mohammed Bouziane Zahi Ismaili Ghizlane Kharrasse |
| author_facet | Fakhrddine Amri Chifaa Belkhayat Asmae yeznasni Hajar Koulali Rachid Jabi Abdelkrim Zazour Naima Abda Mohammed Bouziane Zahi Ismaili Ghizlane Kharrasse |
| author_sort | Fakhrddine Amri |
| collection | DOAJ |
| description | Abstract Background Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. Aims We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the factors associated with type 2 diabetes mellitus in this population. Methods This retrospective observational and analytical study was carried out in the Department of Gastroenterology of the Mohammed VI University Hospital over a period of 5 years, between 2018 and 2022, including all patients with confirmed cases of pancreatic adenocarcinoma. Results Out of the 197 patients, 38.1% had a history of diabetes, among them, 42.7% had new-onset diabetes, while the remaining 57.3% had long-standing diabetes. Diabetic patients were significantly older than nondiabetic patients (mean age of 67.2 vs. 63, P = 0.009). Diabetes was more prevalent among obese patients (66.7%, P = 0.01), and less frequent among individuals with chronic alcohol consumption (20% vs. 80%, P = 0.04), and tobacco smokers (24.4% vs75.6%, P = 0.03). Among patients with an ECOG score ≥ 3, DM, 54.5% were DM-patients (P = 0.033). The same significant association was found for the Nutritional Risk Index, Patients who had moderate or severe malnutrition were more likely to be diabetic 74.7% (P = 0.004). Diabetic patients were less likely to undergo surgery due to comorbidities and general health deterioration. However, no significant differences were observed in sex, tumor stage or location. Conclusion Our study has shown an increased prevalence of diabetes in pancreatic cancer and highlights the importance of considering this cancer in cases of recent onset or uncontrolled diabetes, especially in elderly individuals. |
| first_indexed | 2024-03-09T15:06:34Z |
| format | Article |
| id | doaj.art-246f6a7a4f4841429a2a7a002cbfe7b9 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T15:06:34Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-246f6a7a4f4841429a2a7a002cbfe7b92023-11-26T13:35:49ZengBMCBMC Cancer1471-24072023-09-012311610.1186/s12885-023-11344-wAssociation between pancreatic cancer and diabetes: insights from a retrospective cohort studyFakhrddine Amri0Chifaa Belkhayat1Asmae yeznasni2Hajar Koulali3Rachid Jabi4Abdelkrim Zazour5Naima Abda6Mohammed Bouziane7Zahi Ismaili8Ghizlane Kharrasse9Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityDepartment of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityLaboratory of Epidemiology, Clinical Research, and Public Health, Faculty of Medicine and Pharmacy, Mohammed First UniversityDepartment of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityDepartment of General Surgery, Mohammed VI University HospitalDepartment of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityLaboratory of Epidemiology, Clinical Research, and Public Health, Faculty of Medicine and Pharmacy, Mohammed First UniversityDepartment of General Surgery, Mohammed VI University HospitalDepartment of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityDepartment of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda UniversityAbstract Background Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. Aims We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the factors associated with type 2 diabetes mellitus in this population. Methods This retrospective observational and analytical study was carried out in the Department of Gastroenterology of the Mohammed VI University Hospital over a period of 5 years, between 2018 and 2022, including all patients with confirmed cases of pancreatic adenocarcinoma. Results Out of the 197 patients, 38.1% had a history of diabetes, among them, 42.7% had new-onset diabetes, while the remaining 57.3% had long-standing diabetes. Diabetic patients were significantly older than nondiabetic patients (mean age of 67.2 vs. 63, P = 0.009). Diabetes was more prevalent among obese patients (66.7%, P = 0.01), and less frequent among individuals with chronic alcohol consumption (20% vs. 80%, P = 0.04), and tobacco smokers (24.4% vs75.6%, P = 0.03). Among patients with an ECOG score ≥ 3, DM, 54.5% were DM-patients (P = 0.033). The same significant association was found for the Nutritional Risk Index, Patients who had moderate or severe malnutrition were more likely to be diabetic 74.7% (P = 0.004). Diabetic patients were less likely to undergo surgery due to comorbidities and general health deterioration. However, no significant differences were observed in sex, tumor stage or location. Conclusion Our study has shown an increased prevalence of diabetes in pancreatic cancer and highlights the importance of considering this cancer in cases of recent onset or uncontrolled diabetes, especially in elderly individuals.https://doi.org/10.1186/s12885-023-11344-wPancreatic adenocarcinomaDiabetes mellitusPoor prognosisRisk factors |
| spellingShingle | Fakhrddine Amri Chifaa Belkhayat Asmae yeznasni Hajar Koulali Rachid Jabi Abdelkrim Zazour Naima Abda Mohammed Bouziane Zahi Ismaili Ghizlane Kharrasse Association between pancreatic cancer and diabetes: insights from a retrospective cohort study BMC Cancer Pancreatic adenocarcinoma Diabetes mellitus Poor prognosis Risk factors |
| title | Association between pancreatic cancer and diabetes: insights from a retrospective cohort study |
| title_full | Association between pancreatic cancer and diabetes: insights from a retrospective cohort study |
| title_fullStr | Association between pancreatic cancer and diabetes: insights from a retrospective cohort study |
| title_full_unstemmed | Association between pancreatic cancer and diabetes: insights from a retrospective cohort study |
| title_short | Association between pancreatic cancer and diabetes: insights from a retrospective cohort study |
| title_sort | association between pancreatic cancer and diabetes insights from a retrospective cohort study |
| topic | Pancreatic adenocarcinoma Diabetes mellitus Poor prognosis Risk factors |
| url | https://doi.org/10.1186/s12885-023-11344-w |
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