A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse
It is currently unknown which genetic polymorphisms are involved in substance use disorder (SUD) comorbid with bipolar disorder (BD). The research on polymorphisms in BD comorbid with SUD (BD + SUD) is summarized in this systematic review. We looked for case-control studies that genetically compared...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1303 |
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| author | Adriano de Marco Gabriele Scozia Lucia Manfredi David Conversi |
| author_facet | Adriano de Marco Gabriele Scozia Lucia Manfredi David Conversi |
| author_sort | Adriano de Marco |
| collection | DOAJ |
| description | It is currently unknown which genetic polymorphisms are involved in substance use disorder (SUD) comorbid with bipolar disorder (BD). The research on polymorphisms in BD comorbid with SUD (BD + SUD) is summarized in this systematic review. We looked for case-control studies that genetically compared adults and adolescents with BD and SUD, healthy controls, and BD without SUD. PRISMA was used to create our protocol, which is PROSPERO-registered (identification: CRD4221270818). The following bibliographic databases were searched indefinitely until December 2021 to identify potentially relevant articles: PubMed, PsycINFO, Scopus, and Web of Science. This systematic review, after the qualitative analysis of the study selection, included 17 eligible articles. In the selected studies, 66 polymorphisms in 29 genes were investigated. The present work delivers a group of potentially valuable genetic polymorphisms associated with BD + SUD: rs11600996 (<i>ARNTL</i>), rs228642/rs228682/rs2640909 (<i>PER3</i>), PONQ192R (<i>PON1</i>), rs945032 (<i>BDKRB2</i>), rs1131339 (<i>NR4A3</i>), and rs6971 (<i>TSPO</i>). It is important to note that none of those findings have been confirmed by two or more studies; thus, we believe that all the polymorphisms identified in this review require additional evidence to be confirmed. |
| first_indexed | 2024-03-09T09:56:05Z |
| format | Article |
| id | doaj.art-246f85705c5c4ad8b00d759ff8fdf736 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T09:56:05Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| series | Genes |
| spelling | doaj.art-246f85705c5c4ad8b00d759ff8fdf7362023-12-01T23:43:48ZengMDPI AGGenes2073-44252022-07-01138130310.3390/genes13081303A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance AbuseAdriano de Marco0Gabriele Scozia1Lucia Manfredi2David Conversi3Department of Psychology, Università degli Studi di Roma ‘La Sapienza’, 00185 Rome, ItalyDepartment of Psychology, Università degli Studi di Roma ‘La Sapienza’, 00185 Rome, ItalyDepartment of Psychology, Università degli Studi di Roma ‘La Sapienza’, 00185 Rome, ItalyDepartment of Psychology, Università degli Studi di Roma ‘La Sapienza’, 00185 Rome, ItalyIt is currently unknown which genetic polymorphisms are involved in substance use disorder (SUD) comorbid with bipolar disorder (BD). The research on polymorphisms in BD comorbid with SUD (BD + SUD) is summarized in this systematic review. We looked for case-control studies that genetically compared adults and adolescents with BD and SUD, healthy controls, and BD without SUD. PRISMA was used to create our protocol, which is PROSPERO-registered (identification: CRD4221270818). The following bibliographic databases were searched indefinitely until December 2021 to identify potentially relevant articles: PubMed, PsycINFO, Scopus, and Web of Science. This systematic review, after the qualitative analysis of the study selection, included 17 eligible articles. In the selected studies, 66 polymorphisms in 29 genes were investigated. The present work delivers a group of potentially valuable genetic polymorphisms associated with BD + SUD: rs11600996 (<i>ARNTL</i>), rs228642/rs228682/rs2640909 (<i>PER3</i>), PONQ192R (<i>PON1</i>), rs945032 (<i>BDKRB2</i>), rs1131339 (<i>NR4A3</i>), and rs6971 (<i>TSPO</i>). It is important to note that none of those findings have been confirmed by two or more studies; thus, we believe that all the polymorphisms identified in this review require additional evidence to be confirmed.https://www.mdpi.com/2073-4425/13/8/1303bipolar disordersubstance use disorderpolymorphisms |
| spellingShingle | Adriano de Marco Gabriele Scozia Lucia Manfredi David Conversi A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse Genes bipolar disorder substance use disorder polymorphisms |
| title | A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse |
| title_full | A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse |
| title_fullStr | A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse |
| title_full_unstemmed | A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse |
| title_short | A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse |
| title_sort | systematic review of genetic polymorphisms associated with bipolar disorder comorbid to substance abuse |
| topic | bipolar disorder substance use disorder polymorphisms |
| url | https://www.mdpi.com/2073-4425/13/8/1303 |
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