Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar
<i>Background</i>: Suicidality and brain tumors are two life-threatening conditions and, somewhat unexpectedly, the associations between them have scarcely been reported. <i>Objective</i>: In this study, we aimed to provide a brief literature review of epidemiological studies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/12/725 |
| _version_ | 1797707575665360896 |
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| author | Alessandra Costanza Francesco Zenga Roberta Rudà Andrea Amerio Andrea Aguglia Gianluca Serafini Mario Amore Guido Bondolfi Isabella Berardelli Khoa Dinh Nguyen |
| author_facet | Alessandra Costanza Francesco Zenga Roberta Rudà Andrea Amerio Andrea Aguglia Gianluca Serafini Mario Amore Guido Bondolfi Isabella Berardelli Khoa Dinh Nguyen |
| author_sort | Alessandra Costanza |
| collection | DOAJ |
| description | <i>Background</i>: Suicidality and brain tumors are two life-threatening conditions and, somewhat unexpectedly, the associations between them have scarcely been reported. <i>Objective</i>: In this study, we aimed to provide a brief literature review of epidemiological studies on suicidal ideation (SI) and suicidal behavior (SB) in patients with brain tumors. To illustrate various aspects of brain tumors that potentially underlie the emergence of suicidality, the review is supplemented with a clinical exemplar of a long-term survivor of brain tumor (glioblastoma) who experienced persistent SI. Furthermore, we discuss putative both neurobiological (including anatomical and immunological) and psychosocial mechanisms that might be accountable for the development of SI and SB in patients with brain tumors. <i>Conclusions</i>: While the etiology of this phenomenon appears to be multifactorial and still remains a subject of much debate, it is of critical importance to identify patients for which a psychiatric evaluation could recognize, in a timely manner, a possible suicide risk and alleviate the deep related suffering, by appropriate psychopharmacological and supportive and psychotherapeutic interventions. |
| first_indexed | 2024-03-12T06:08:24Z |
| format | Article |
| id | doaj.art-24703d03e2c04718934e4737d451d649 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:08:24Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-24703d03e2c04718934e4737d451d6492023-09-03T03:19:46ZengMDPI AGMedicina1010-660X2020-12-015672572510.3390/medicina56120725Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical ExemplarAlessandra Costanza0Francesco Zenga1Roberta Rudà2Andrea Amerio3Andrea Aguglia4Gianluca Serafini5Mario Amore6Guido Bondolfi7Isabella Berardelli8Khoa Dinh Nguyen9Department of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), 1211 Geneva, SwitzerlandDepartment of Neurosurgery, University and City of Health and Science Hospital, 10126 Torino, ItalyDepartment of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Torino, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16133 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16133 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16133 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16133 Genoa, ItalyDepartment of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), 1211 Geneva, SwitzerlandDepartment of Neuroscience, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Microbiology and Immunology, Stanford University, Palo Alto, CA 94305, USA<i>Background</i>: Suicidality and brain tumors are two life-threatening conditions and, somewhat unexpectedly, the associations between them have scarcely been reported. <i>Objective</i>: In this study, we aimed to provide a brief literature review of epidemiological studies on suicidal ideation (SI) and suicidal behavior (SB) in patients with brain tumors. To illustrate various aspects of brain tumors that potentially underlie the emergence of suicidality, the review is supplemented with a clinical exemplar of a long-term survivor of brain tumor (glioblastoma) who experienced persistent SI. Furthermore, we discuss putative both neurobiological (including anatomical and immunological) and psychosocial mechanisms that might be accountable for the development of SI and SB in patients with brain tumors. <i>Conclusions</i>: While the etiology of this phenomenon appears to be multifactorial and still remains a subject of much debate, it is of critical importance to identify patients for which a psychiatric evaluation could recognize, in a timely manner, a possible suicide risk and alleviate the deep related suffering, by appropriate psychopharmacological and supportive and psychotherapeutic interventions.https://www.mdpi.com/1010-660X/56/12/725brain tumorglioblastomagliomasuicidesuicidal ideationsuicide attempt |
| spellingShingle | Alessandra Costanza Francesco Zenga Roberta Rudà Andrea Amerio Andrea Aguglia Gianluca Serafini Mario Amore Guido Bondolfi Isabella Berardelli Khoa Dinh Nguyen Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar Medicina brain tumor glioblastoma glioma suicide suicidal ideation suicide attempt |
| title | Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar |
| title_full | Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar |
| title_fullStr | Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar |
| title_full_unstemmed | Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar |
| title_short | Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar |
| title_sort | suicidality in patients with brain tumors a brief literature review with clinical exemplar |
| topic | brain tumor glioblastoma glioma suicide suicidal ideation suicide attempt |
| url | https://www.mdpi.com/1010-660X/56/12/725 |
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