The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs
Objectives . To evaluate carotid artery intima-media thickness (CIMT) and lipid profile in children with epilepsy on long-term antiepileptic drug (AED) monotherapy. Methods . We included 60 children with epilepsy receiving valproate, carbamazepine, or levetiracetam monotherapy and 60 controls. A hig...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X231200205 |
| _version_ | 1797663792974266368 |
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| author | Khaled Amin Nasef MD Moustafa Kotb Elmala MD Alsayed Mohamed Sayed Ahmed MD Ashraf Hamed Al-shokary MD Asmaa Obada Ibrahim MD Naglaa M. Kamal MD Hany Abdelaziz Suliman MD Nageh Shehata Ismail MD Ahmed Sobhi MD Hatem Hamed Elshorbagy MD Ahmed Maher Abdelnasser MD Ahmed Abdallah Torky MD Waleed Elsayed Abdelghani MD |
| author_facet | Khaled Amin Nasef MD Moustafa Kotb Elmala MD Alsayed Mohamed Sayed Ahmed MD Ashraf Hamed Al-shokary MD Asmaa Obada Ibrahim MD Naglaa M. Kamal MD Hany Abdelaziz Suliman MD Nageh Shehata Ismail MD Ahmed Sobhi MD Hatem Hamed Elshorbagy MD Ahmed Maher Abdelnasser MD Ahmed Abdallah Torky MD Waleed Elsayed Abdelghani MD |
| author_sort | Khaled Amin Nasef MD |
| collection | DOAJ |
| description | Objectives . To evaluate carotid artery intima-media thickness (CIMT) and lipid profile in children with epilepsy on long-term antiepileptic drug (AED) monotherapy. Methods . We included 60 children with epilepsy receiving valproate, carbamazepine, or levetiracetam monotherapy and 60 controls. A high-resolution B-mode ultrasound was used to measure (CIMT). Measurement of serum lipids was done. Results . Patients on valproate (0.44 ± 0.03, P ≤ .001), carbamazepine (0.43 ± 0.03with P ≤ .001), and levetiracetam (0.44 ± 0.02 with P ≤ .001) monotherapy showed significantly higher CIMT compared to controls. CIMT was correlated with age ( P = .041, r = .112) AEDs{valproate ( P = .005, r = .731), carbamazepine ( P = .038, r = .365), and levetiracetam ( P = .036, r = .155)}, duration of treatment ( P = .001, r = .313), TC( P = .001, r = .192), TG ( P = .014, r = .018), and LDL ( P = .001, r = .219). HDL ( P = .003, r = −.126). Seizure severity and Apo A1 were insignificantly involved. Conclusion . Long-term monotherapy with valproate, carbamazepine, and levetiracetam in epileptic children was associated with significant abnormalities in CIMT. |
| first_indexed | 2024-03-11T19:20:49Z |
| format | Article |
| id | doaj.art-24705096391f4abfb4b84876b43fb468 |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-03-11T19:20:49Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-24705096391f4abfb4b84876b43fb4682023-10-07T09:04:17ZengSAGE PublishingGlobal Pediatric Health2333-794X2023-10-011010.1177/2333794X231200205The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic DrugsKhaled Amin Nasef MD0Moustafa Kotb Elmala MD1Alsayed Mohamed Sayed Ahmed MD2Ashraf Hamed Al-shokary MD3Asmaa Obada Ibrahim MD4Naglaa M. Kamal MD5Hany Abdelaziz Suliman MD6Nageh Shehata Ismail MD7Ahmed Sobhi MD8Hatem Hamed Elshorbagy MD9Ahmed Maher Abdelnasser MD10Ahmed Abdallah Torky MD11Waleed Elsayed Abdelghani MD12Cairo University, Cairo, EgyptNizwa Hospital, Nizwa, Sultanate of OmanMadinat Zayed Hospital, SEHA, Abu Dhabi, United Arab EmiratesBenha University, Benha, EgyptAin Shams University, Cairo, EgyptCairo University, Cairo, EgyptBenha University, Benha, EgyptMinia University, Minya, EgyptCairo University, Cairo, EgyptMenoufia University, Shebeen Elkom, EgyptBenha University, Benha, EgyptBenha University, Benha, EgyptBenha University, Benha, EgyptObjectives . To evaluate carotid artery intima-media thickness (CIMT) and lipid profile in children with epilepsy on long-term antiepileptic drug (AED) monotherapy. Methods . We included 60 children with epilepsy receiving valproate, carbamazepine, or levetiracetam monotherapy and 60 controls. A high-resolution B-mode ultrasound was used to measure (CIMT). Measurement of serum lipids was done. Results . Patients on valproate (0.44 ± 0.03, P ≤ .001), carbamazepine (0.43 ± 0.03with P ≤ .001), and levetiracetam (0.44 ± 0.02 with P ≤ .001) monotherapy showed significantly higher CIMT compared to controls. CIMT was correlated with age ( P = .041, r = .112) AEDs{valproate ( P = .005, r = .731), carbamazepine ( P = .038, r = .365), and levetiracetam ( P = .036, r = .155)}, duration of treatment ( P = .001, r = .313), TC( P = .001, r = .192), TG ( P = .014, r = .018), and LDL ( P = .001, r = .219). HDL ( P = .003, r = −.126). Seizure severity and Apo A1 were insignificantly involved. Conclusion . Long-term monotherapy with valproate, carbamazepine, and levetiracetam in epileptic children was associated with significant abnormalities in CIMT.https://doi.org/10.1177/2333794X231200205 |
| spellingShingle | Khaled Amin Nasef MD Moustafa Kotb Elmala MD Alsayed Mohamed Sayed Ahmed MD Ashraf Hamed Al-shokary MD Asmaa Obada Ibrahim MD Naglaa M. Kamal MD Hany Abdelaziz Suliman MD Nageh Shehata Ismail MD Ahmed Sobhi MD Hatem Hamed Elshorbagy MD Ahmed Maher Abdelnasser MD Ahmed Abdallah Torky MD Waleed Elsayed Abdelghani MD The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs Global Pediatric Health |
| title | The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs |
| title_full | The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs |
| title_fullStr | The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs |
| title_full_unstemmed | The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs |
| title_short | The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs |
| title_sort | study of carotid artery intima media thickness in children with epilepsy on anti epileptic drugs |
| url | https://doi.org/10.1177/2333794X231200205 |
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