Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke
Abstract Perinatal stroke causes most hemiparetic cerebral palsy and cognitive dysfunction may co-occur. Compensatory developmental changes in the intact contralesional hemisphere may mediate residual function and represent targets for neuromodulation. We used morphometry to explore cortical thickne...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38185-8 |
| _version_ | 1797778886336970752 |
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| author | Karan Shinde Brandon T. Craig Jordan Hassett Nomazulu Dlamini Brian L. Brooks Adam Kirton Helen L. Carlson |
| author_facet | Karan Shinde Brandon T. Craig Jordan Hassett Nomazulu Dlamini Brian L. Brooks Adam Kirton Helen L. Carlson |
| author_sort | Karan Shinde |
| collection | DOAJ |
| description | Abstract Perinatal stroke causes most hemiparetic cerebral palsy and cognitive dysfunction may co-occur. Compensatory developmental changes in the intact contralesional hemisphere may mediate residual function and represent targets for neuromodulation. We used morphometry to explore cortical thickness, grey matter volume, gyrification, and sulcal depth of the contralesional hemisphere in children, adolescents, and young adults after perinatal stroke and explored associations with motor, attention, and executive function. Participants aged 6–20 years (N = 109, 63% male) with unilateral perinatal stroke underwent T1-weighted imaging. Participants had arterial ischemic stroke (AIS; n = 36), periventricular venous infarction (PVI; n = 37) or were controls (n = 36). Morphometry was performed using the Computational Anatomy Toolbox (CAT12). Group differences and associations with motor and executive function (in a smaller subsample) were assessed. Group comparisons revealed areas of lower cortical thickness in contralesional hemispheres in both AIS and PVI and greater gyrification in AIS compared to controls. Areas of greater grey matter volume and sulcal depth were also seen for AIS. The PVI group showed lower grey matter volume in cingulate cortex and less volume in precuneus relative to controls. No associations were found between morphometry metrics, motor, attention, and executive function. Cortical structure of the intact contralesional hemisphere is altered after perinatal stroke. Alterations in contralesional cortical morphometry shown in perinatal stroke may be associated with different mechanisms of damage or timing of early injury. Further investigations with larger samples are required to more thoroughly explore associations with motor and cognitive function. |
| first_indexed | 2024-03-12T23:23:58Z |
| format | Article |
| id | doaj.art-247086b9458b49ed8d41708c55efe164 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T23:23:58Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-247086b9458b49ed8d41708c55efe1642023-07-16T11:16:03ZengNature PortfolioScientific Reports2045-23222023-07-0113111210.1038/s41598-023-38185-8Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal strokeKaran Shinde0Brandon T. Craig1Jordan Hassett2Nomazulu Dlamini3Brian L. Brooks4Adam Kirton5Helen L. Carlson6Department of Pediatrics, Cumming School of Medicine, University of CalgaryDepartment of Pediatrics, Cumming School of Medicine, University of CalgaryDepartment of Pediatrics, Cumming School of Medicine, University of CalgaryChildren’s Stroke Program, Hospital for Sick ChildrenDepartment of Pediatrics, Cumming School of Medicine, University of CalgaryDepartment of Pediatrics, Cumming School of Medicine, University of CalgaryDepartment of Pediatrics, Cumming School of Medicine, University of CalgaryAbstract Perinatal stroke causes most hemiparetic cerebral palsy and cognitive dysfunction may co-occur. Compensatory developmental changes in the intact contralesional hemisphere may mediate residual function and represent targets for neuromodulation. We used morphometry to explore cortical thickness, grey matter volume, gyrification, and sulcal depth of the contralesional hemisphere in children, adolescents, and young adults after perinatal stroke and explored associations with motor, attention, and executive function. Participants aged 6–20 years (N = 109, 63% male) with unilateral perinatal stroke underwent T1-weighted imaging. Participants had arterial ischemic stroke (AIS; n = 36), periventricular venous infarction (PVI; n = 37) or were controls (n = 36). Morphometry was performed using the Computational Anatomy Toolbox (CAT12). Group differences and associations with motor and executive function (in a smaller subsample) were assessed. Group comparisons revealed areas of lower cortical thickness in contralesional hemispheres in both AIS and PVI and greater gyrification in AIS compared to controls. Areas of greater grey matter volume and sulcal depth were also seen for AIS. The PVI group showed lower grey matter volume in cingulate cortex and less volume in precuneus relative to controls. No associations were found between morphometry metrics, motor, attention, and executive function. Cortical structure of the intact contralesional hemisphere is altered after perinatal stroke. Alterations in contralesional cortical morphometry shown in perinatal stroke may be associated with different mechanisms of damage or timing of early injury. Further investigations with larger samples are required to more thoroughly explore associations with motor and cognitive function.https://doi.org/10.1038/s41598-023-38185-8 |
| spellingShingle | Karan Shinde Brandon T. Craig Jordan Hassett Nomazulu Dlamini Brian L. Brooks Adam Kirton Helen L. Carlson Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke Scientific Reports |
| title | Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke |
| title_full | Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke |
| title_fullStr | Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke |
| title_full_unstemmed | Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke |
| title_short | Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke |
| title_sort | alterations in cortical morphometry of the contralesional hemisphere in children adolescents and young adults with perinatal stroke |
| url | https://doi.org/10.1038/s41598-023-38185-8 |
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