Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline.
The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results ind...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4096727?pdf=render |
| _version_ | 1811192018433474560 |
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| author | Zhenxing Chi Rutao Liu Hong You Shanshan Ma Hao Cui Qiang Zhang |
| author_facet | Zhenxing Chi Rutao Liu Hong You Shanshan Ma Hao Cui Qiang Zhang |
| author_sort | Zhenxing Chi |
| collection | DOAJ |
| description | The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo. |
| first_indexed | 2024-04-11T23:46:19Z |
| format | Article |
| id | doaj.art-247195d5e3d74917bb0ad0e77bd9f673 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:46:19Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-247195d5e3d74917bb0ad0e77bd9f6732022-12-22T03:56:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10233410.1371/journal.pone.0102334Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline.Zhenxing ChiRutao LiuHong YouShanshan MaHao CuiQiang ZhangThe study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo.http://europepmc.org/articles/PMC4096727?pdf=render |
| spellingShingle | Zhenxing Chi Rutao Liu Hong You Shanshan Ma Hao Cui Qiang Zhang Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. PLoS ONE |
| title | Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. |
| title_full | Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. |
| title_fullStr | Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. |
| title_full_unstemmed | Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. |
| title_short | Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline. |
| title_sort | probing the in vitro cytotoxicity of the veterinary drug oxytetracycline |
| url | http://europepmc.org/articles/PMC4096727?pdf=render |
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