HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer
Head and neck cancer (HNC) is the sixth most common cancer worldwide. Over the last decade, an enormous amount of well-annotated gene and drug data has accumulated for HNC. However, a comprehensive repository is not yet available. Here, we constructed the Head and Neck Cancer Database (HNCDB: http:/...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00371/full |
| _version_ | 1811303421028859904 |
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| author | Qingbin Zhang Xingyang Li Xuan Su Hongwan Zhang Hanbing Wang Sanjun Yin Xiaoqing Pei Ankui Yang Zhixiang Zuo |
| author_facet | Qingbin Zhang Xingyang Li Xuan Su Hongwan Zhang Hanbing Wang Sanjun Yin Xiaoqing Pei Ankui Yang Zhixiang Zuo |
| author_sort | Qingbin Zhang |
| collection | DOAJ |
| description | Head and neck cancer (HNC) is the sixth most common cancer worldwide. Over the last decade, an enormous amount of well-annotated gene and drug data has accumulated for HNC. However, a comprehensive repository is not yet available. Here, we constructed the Head and Neck Cancer Database (HNCDB: http://hncdb.cancerbio.info) using text mining followed by manual curation of the literature to collect reliable information on the HNC-related genes and drugs. The high-throughput gene expression data for HNC were also integrated into HNCDB. HNCDB includes the following three separate but closely related components: “HNC GENE,” “Connectivity Map,” and “ANALYSIS.” The “HNC GENE” component contains comprehensive information for the 1,173 HNC-related genes manually curated from 2,564 publications. The “Connectivity Map” includes information on the potential connections between the 176 drugs manually curated from 2,032 publications and the 1,173 HNC-related genes. The “ANALYSIS” component allows users to conduct correlation, differential expression, and survival analyses in the 2,403 samples from 78 HNC gene expression datasets. Taken together, we believe that HNCDB will be of significant benefit for the HNC community and promote further advances for precision medicine research on HNC. |
| first_indexed | 2024-04-13T07:47:41Z |
| format | Article |
| id | doaj.art-2473d459619243529e2eba045fa3da15 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T07:47:41Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2473d459619243529e2eba045fa3da152022-12-22T02:55:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-05-01910.3389/fonc.2019.00371456302HNCDB: An Integrated Gene and Drug Database for Head and Neck CancerQingbin Zhang0Xingyang Li1Xuan Su2Hongwan Zhang3Hanbing Wang4Sanjun Yin5Xiaoqing Pei6Ankui Yang7Zhixiang Zuo8Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cancer Biology, Health Time Gene Institute, Shenzhen, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, ChinaHead and neck cancer (HNC) is the sixth most common cancer worldwide. Over the last decade, an enormous amount of well-annotated gene and drug data has accumulated for HNC. However, a comprehensive repository is not yet available. Here, we constructed the Head and Neck Cancer Database (HNCDB: http://hncdb.cancerbio.info) using text mining followed by manual curation of the literature to collect reliable information on the HNC-related genes and drugs. The high-throughput gene expression data for HNC were also integrated into HNCDB. HNCDB includes the following three separate but closely related components: “HNC GENE,” “Connectivity Map,” and “ANALYSIS.” The “HNC GENE” component contains comprehensive information for the 1,173 HNC-related genes manually curated from 2,564 publications. The “Connectivity Map” includes information on the potential connections between the 176 drugs manually curated from 2,032 publications and the 1,173 HNC-related genes. The “ANALYSIS” component allows users to conduct correlation, differential expression, and survival analyses in the 2,403 samples from 78 HNC gene expression datasets. Taken together, we believe that HNCDB will be of significant benefit for the HNC community and promote further advances for precision medicine research on HNC.https://www.frontiersin.org/article/10.3389/fonc.2019.00371/fullhead and neck cancergenedrugconnectivity mapexpression analysis |
| spellingShingle | Qingbin Zhang Xingyang Li Xuan Su Hongwan Zhang Hanbing Wang Sanjun Yin Xiaoqing Pei Ankui Yang Zhixiang Zuo HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer Frontiers in Oncology head and neck cancer gene drug connectivity map expression analysis |
| title | HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer |
| title_full | HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer |
| title_fullStr | HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer |
| title_full_unstemmed | HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer |
| title_short | HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer |
| title_sort | hncdb an integrated gene and drug database for head and neck cancer |
| topic | head and neck cancer gene drug connectivity map expression analysis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00371/full |
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