Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models

Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models

Embolism, hyperglycemia, high intraocular pressure-induced increased reactive oxygen species (ROS) production, and microglial activation result in endothelial/retinal ganglion cell death. Here, we conducted in vitro and in vivo ischemia/reperfusion (I/R) efficacy studies of a hybrid antioxidant–nitr...

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Bibliographic Details
Main Authors: Charles E. Amankwa, Lorea Gamboa Acha, Adnan Dibas, Sai H. Chavala, Steven Roth, Biji Mathew, Suchismita Acharya
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
oxidative stress
<b>SA-10</b>
NO donor
hybrid antioxidants
inflammation
microglia
Online Access:https://www.mdpi.com/2073-4409/13/5/396

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