T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.

T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.

T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse. Coordination of the activation, recruitment, and signaling from T cell receptor...

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Bibliographic Details
Main Authors: Mariano Sanchez-Lockhart, Ana V Rojas, Margaret M Fettis, Richard Bauserman, Trissha R Higa, Hongyu Miao, Richard E Waugh, Jim Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933428?pdf=render

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