Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn’s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Nacional de Salud
2018-03-01
|
| Series: | Biomédica: revista del Instituto Nacional de Salud |
| Subjects: | |
| Online Access: | https://www.revistabiomedica.org/index.php/biomedica/article/view/3273 |
| _version_ | 1818501871718891520 |
|---|---|
| author | Leandro Galvis Ángel Y. Sánchez Leonardo F. Jurado Martha I. Murcia |
| author_facet | Leandro Galvis Ángel Y. Sánchez Leonardo F. Jurado Martha I. Murcia |
| author_sort | Leandro Galvis |
| collection | DOAJ |
| description | Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn’s disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections.
We report the case of a 68-year-old man with Crohn’s disease, who developed disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays.
We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis. |
| first_indexed | 2024-12-10T21:02:15Z |
| format | Article |
| id | doaj.art-2476996fa15c4f2ab6ca6bed8d7dc8b5 |
| institution | Directory Open Access Journal |
| issn | 0120-4157 0120-4157 |
| language | English |
| last_indexed | 2024-12-10T21:02:15Z |
| publishDate | 2018-03-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Biomédica: revista del Instituto Nacional de Salud |
| spelling | doaj.art-2476996fa15c4f2ab6ca6bed8d7dc8b52022-12-22T01:33:45ZengInstituto Nacional de SaludBiomédica: revista del Instituto Nacional de Salud0120-41570120-41572018-03-0138171610.7705/biomedica.v38i0.32732045Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in ColombiaLeandro Galvis0Ángel Y. Sánchez1Leonardo F. Jurado2Martha I. Murcia3Laboratorio de Patología, Clínica San José, San José de Cúcuta, ColombiaDepartamento de Patología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., ColombiaGrupo de Investigación MICOBAC-UN, Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia Departamento de Patología y Laboratorios, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, D.C., ColombiaGrupo de Investigación MICOBAC-UN, Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., ColombiaTumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn’s disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections. We report the case of a 68-year-old man with Crohn’s disease, who developed disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays. We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis.https://www.revistabiomedica.org/index.php/biomedica/article/view/3273Mycobacterium tuberculosistuberculosislatent tuberculosisCronh’s diseasediagnosisrisk factortumor necrosis factor-alphaColombia |
| spellingShingle | Leandro Galvis Ángel Y. Sánchez Leonardo F. Jurado Martha I. Murcia Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia Biomédica: revista del Instituto Nacional de Salud Mycobacterium tuberculosis tuberculosis latent tuberculosis Cronh’s disease diagnosis risk factor tumor necrosis factor-alpha Colombia |
| title | Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia |
| title_full | Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia |
| title_fullStr | Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia |
| title_full_unstemmed | Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia |
| title_short | Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia |
| title_sort | tuberculosis associated with tumor necrosis factor α antagonists case description and analysis of reported cases in colombia |
| topic | Mycobacterium tuberculosis tuberculosis latent tuberculosis Cronh’s disease diagnosis risk factor tumor necrosis factor-alpha Colombia |
| url | https://www.revistabiomedica.org/index.php/biomedica/article/view/3273 |
| work_keys_str_mv | AT leandrogalvis tuberculosisassociatedwithtumornecrosisfactoraantagonistscasedescriptionandanalysisofreportedcasesincolombia AT angelysanchez tuberculosisassociatedwithtumornecrosisfactoraantagonistscasedescriptionandanalysisofreportedcasesincolombia AT leonardofjurado tuberculosisassociatedwithtumornecrosisfactoraantagonistscasedescriptionandanalysisofreportedcasesincolombia AT marthaimurcia tuberculosisassociatedwithtumornecrosisfactoraantagonistscasedescriptionandanalysisofreportedcasesincolombia |