Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin

Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin

Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological research in developing synthetic inhibitors of TRPV6, natural compounds acting at this channel have been largely neglected. On the other hand...

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Main Authors: Arthur Neuberger, Yury A. Trofimov, Maria V. Yelshanskaya, Jeffrey Khau, Kirill D. Nadezhdin, Lena S. Khosrof, Nikolay A. Krylov, Roman G. Efremov, Alexander I. Sobolevsky
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40362-2

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