Development and validation of the scale for symptom clusters in patients with myasthenia gravis
Abstract Background Patients with myasthenia gravis(MG)often experience multiple symptoms concurrently, which can have an adverse effect on their quality of life(QOL). However, a specific, systemic and reliable scale for symptom clusters in MG is lacking. Aims To develop reliable assessment scale fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03240-4 |
| _version_ | 1797822787404955648 |
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| author | Fan Shen Lu-Hong Hu Hai-Shan Huang Ling Li |
| author_facet | Fan Shen Lu-Hong Hu Hai-Shan Huang Ling Li |
| author_sort | Fan Shen |
| collection | DOAJ |
| description | Abstract Background Patients with myasthenia gravis(MG)often experience multiple symptoms concurrently, which can have an adverse effect on their quality of life(QOL). However, a specific, systemic and reliable scale for symptom clusters in MG is lacking. Aims To develop reliable assessment scale for symptom clusters in patients with MG. Design A cross-sectional descriptive study. Methods Based on the unpleasant symptom theory(TOUS), the first draft of the scale was developed through review literature, qualitative interview, and Delphi expert correspondence, the items of the scale were presented and adjusted through cognitive interviews with 12 patients. To conveniently assess the validity and reliability of the scale, a cross-sectional survey was conducted in 283 patients with MG who were recruited from Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, from June to September 2021. Results The final symptom cluster scale for patients with MG consisted of 19 items(MGSC-19), with a content validity index ranging from 0.828 to 1.000 for each item and the content validity index was 0.980. Four common variables (ocular muscle weakness, general muscular weakness, treatment-related side effects, and psychiatric problems) were identified by exploratory factor analysis, which explained 70.187% of the total variance. The correlation coefficients between the scale dimension and the overall score ranged from 0.395 to 0.769 (all P < 0.01), while the correlation coefficients between dimensions varied from 0.324 to 0.510 (all P < 0.01). The Cronbach’s alpha, retest reliability, and half reliability were 0.932, 0.845, and 0.837, respectively. Conclusion The validity and reliability of MGSC-19 were generally good. This scale can be employed to identify the symptom clusters to help healthcare givers develop individualized symptom management measures for patients with MG. |
| first_indexed | 2024-03-13T10:14:20Z |
| format | Article |
| id | doaj.art-247759f28ede473eaf8a324268f9608f |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-13T10:14:20Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-247759f28ede473eaf8a324268f9608f2023-05-21T11:19:28ZengBMCBMC Neurology1471-23772023-05-012311810.1186/s12883-023-03240-4Development and validation of the scale for symptom clusters in patients with myasthenia gravisFan Shen0Lu-Hong Hu1Hai-Shan Huang2Ling Li3Nursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Patients with myasthenia gravis(MG)often experience multiple symptoms concurrently, which can have an adverse effect on their quality of life(QOL). However, a specific, systemic and reliable scale for symptom clusters in MG is lacking. Aims To develop reliable assessment scale for symptom clusters in patients with MG. Design A cross-sectional descriptive study. Methods Based on the unpleasant symptom theory(TOUS), the first draft of the scale was developed through review literature, qualitative interview, and Delphi expert correspondence, the items of the scale were presented and adjusted through cognitive interviews with 12 patients. To conveniently assess the validity and reliability of the scale, a cross-sectional survey was conducted in 283 patients with MG who were recruited from Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, from June to September 2021. Results The final symptom cluster scale for patients with MG consisted of 19 items(MGSC-19), with a content validity index ranging from 0.828 to 1.000 for each item and the content validity index was 0.980. Four common variables (ocular muscle weakness, general muscular weakness, treatment-related side effects, and psychiatric problems) were identified by exploratory factor analysis, which explained 70.187% of the total variance. The correlation coefficients between the scale dimension and the overall score ranged from 0.395 to 0.769 (all P < 0.01), while the correlation coefficients between dimensions varied from 0.324 to 0.510 (all P < 0.01). The Cronbach’s alpha, retest reliability, and half reliability were 0.932, 0.845, and 0.837, respectively. Conclusion The validity and reliability of MGSC-19 were generally good. This scale can be employed to identify the symptom clusters to help healthcare givers develop individualized symptom management measures for patients with MG.https://doi.org/10.1186/s12883-023-03240-4Myasthenia gravisSymptom clustersScaleUnpleasant symptom theoryReliabilityValidity |
| spellingShingle | Fan Shen Lu-Hong Hu Hai-Shan Huang Ling Li Development and validation of the scale for symptom clusters in patients with myasthenia gravis BMC Neurology Myasthenia gravis Symptom clusters Scale Unpleasant symptom theory Reliability Validity |
| title | Development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| title_full | Development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| title_fullStr | Development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| title_full_unstemmed | Development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| title_short | Development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| title_sort | development and validation of the scale for symptom clusters in patients with myasthenia gravis |
| topic | Myasthenia gravis Symptom clusters Scale Unpleasant symptom theory Reliability Validity |
| url | https://doi.org/10.1186/s12883-023-03240-4 |
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