The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
<p>Abstract</p> <p>Background</p> <p>Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC...
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| Fformat: | Erthygl |
| Iaith: | English |
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Elsevier
2011-10-01
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| Cyfres: | Journal of Cardiovascular Magnetic Resonance |
| Pynciau: | |
| Mynediad Ar-lein: | http://www.jcmr-online.com/content/13/1/67 |
| _version_ | 1827280346105774080 |
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| author | Katoh Hideki Wakabayashi Yasushi Nagasaka Shiro Takeuchi Yasuyo Sano Makoto Makino Kiwa Kasahara Kazuyuki Sato Akira Naruse Yoshihisa Satoh Hiroshi Hayashi Hideharu Aonuma Kazutaka |
| author_facet | Katoh Hideki Wakabayashi Yasushi Nagasaka Shiro Takeuchi Yasuyo Sano Makoto Makino Kiwa Kasahara Kazuyuki Sato Akira Naruse Yoshihisa Satoh Hiroshi Hayashi Hideharu Aonuma Kazutaka |
| author_sort | Katoh Hideki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC).</p> <p>Methods</p> <p>We evaluated 20 consecutive patients (2 men, 18 women; median age, 77 years; interquartile range [IQR] 67-82 years) who were admitted to our hospital with the diagnosis of TTC. CMR was performed within 1 week after admission, and follow-up studies were conducted 1.5 and 6 months later.</p> <p>Results</p> <p>In 8 patients, CMR imaging during the sub-acute phase revealed LGE in the area matched with wall motion impairment. Cardiogenic shock was more frequently observed in patients with LGE than in those without LGE (38% vs 0%, p = 0.049). The patients with LGE needed a longer duration for ECG normalization and recovery of wall motion than did those without LGE (median 205 days, IQR [152-363] vs 68 days, [43-145], p = 0.005; 15 days, [10-185] vs 7 days, [4-13], p = 0.030, respectively). In 5 of these 8 patients, LGE disappeared within 45-180 days (170, IQR [56-180]) of onset. The patients with LGE remaining in the chronic phase had higher peak creatine kinase levels than did those without LGE (median 307 IU/L, IQR [264-460] vs 202 IU/L, [120-218], p = 0.017).</p> <p>Conclusion</p> <p>LGE by CMR in the sub-acute phase may be associated with the severity and prolonged recovery to normal of clinical findings in TTC.</p> |
| first_indexed | 2024-04-12T23:39:01Z |
| format | Article |
| id | doaj.art-247b49205cd74d1d945a80b5a25e1ca1 |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:35:19Z |
| publishDate | 2011-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-247b49205cd74d1d945a80b5a25e1ca12024-04-16T17:00:34ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2011-10-011316710.1186/1532-429X-13-67The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance imagesKatoh HidekiWakabayashi YasushiNagasaka ShiroTakeuchi YasuyoSano MakotoMakino KiwaKasahara KazuyukiSato AkiraNaruse YoshihisaSatoh HiroshiHayashi HideharuAonuma Kazutaka<p>Abstract</p> <p>Background</p> <p>Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC).</p> <p>Methods</p> <p>We evaluated 20 consecutive patients (2 men, 18 women; median age, 77 years; interquartile range [IQR] 67-82 years) who were admitted to our hospital with the diagnosis of TTC. CMR was performed within 1 week after admission, and follow-up studies were conducted 1.5 and 6 months later.</p> <p>Results</p> <p>In 8 patients, CMR imaging during the sub-acute phase revealed LGE in the area matched with wall motion impairment. Cardiogenic shock was more frequently observed in patients with LGE than in those without LGE (38% vs 0%, p = 0.049). The patients with LGE needed a longer duration for ECG normalization and recovery of wall motion than did those without LGE (median 205 days, IQR [152-363] vs 68 days, [43-145], p = 0.005; 15 days, [10-185] vs 7 days, [4-13], p = 0.030, respectively). In 5 of these 8 patients, LGE disappeared within 45-180 days (170, IQR [56-180]) of onset. The patients with LGE remaining in the chronic phase had higher peak creatine kinase levels than did those without LGE (median 307 IU/L, IQR [264-460] vs 202 IU/L, [120-218], p = 0.017).</p> <p>Conclusion</p> <p>LGE by CMR in the sub-acute phase may be associated with the severity and prolonged recovery to normal of clinical findings in TTC.</p>http://www.jcmr-online.com/content/13/1/67Takotsubo cardiomyopathyCardiac magnetic resonanceCardiac dysfunction |
| spellingShingle | Katoh Hideki Wakabayashi Yasushi Nagasaka Shiro Takeuchi Yasuyo Sano Makoto Makino Kiwa Kasahara Kazuyuki Sato Akira Naruse Yoshihisa Satoh Hiroshi Hayashi Hideharu Aonuma Kazutaka The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images Journal of Cardiovascular Magnetic Resonance Takotsubo cardiomyopathy Cardiac magnetic resonance Cardiac dysfunction |
| title | The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images |
| title_full | The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images |
| title_fullStr | The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images |
| title_full_unstemmed | The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images |
| title_short | The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images |
| title_sort | clinical impact of late gadolinium enhancement in takotsubo cardiomyopathy serial analysis of cardiovascular magnetic resonance images |
| topic | Takotsubo cardiomyopathy Cardiac magnetic resonance Cardiac dysfunction |
| url | http://www.jcmr-online.com/content/13/1/67 |
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