Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study
Introduction: Sickle Cell Disease (SCD) is a common haemoglobinopathy, where spleen is considered to be the first organ to be involved. Although it initially undergoes enlargement, but most often there occurs autosplenectomy. But in some cases, there is persistence of splenomegaly which may be a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/17029/57815_CE(AD)_F[SH]_PF1(AG_SS)_PFA(SS)_PB(AG_SS)_PN(SS).pdf |
| Summary: | Introduction: Sickle Cell Disease (SCD) is a common
haemoglobinopathy, where spleen is considered to be the first
organ to be involved. Although it initially undergoes enlargement,
but most often there occurs autosplenectomy. But in some cases,
there is persistence of splenomegaly which may be associated
with various complications. In these situations, splenectomy is
considered as a good option to mitigate all these morbidities.
Aim: To analyse the effect of splenectomy on haematological
parameters and complications in patients of SCD in postoperative
period.
Materials and Methods: This was a retrospective study
conducted at SLN Medical College and Hospital, Koraput,
Odisha, India, from April 2019 to March 2021. Total 42 patients
of SCD underwent splenectomy. The haematological parameters
{Haemoglobin (Hb), Total Leukocyte Count (TLC) and Total Platelet Count (TPC)} and blood transfusion needs were compared in
preoperative and postoperative periods and analysed statistically
with Student’s t-test.
Results: Primary indication of splenectomy was hypersplenism
31 (73.8%) followed by splenic sequestration crisis in 8
patients (19.05%) and splenic abscess in 3 patients (7.1%).
Postsplenectomy haemoglobin improvement was around 5.17
gm% (p-value<0.001). Postoperative complication was also
minimal, seen in only eight patients, it was mostly due to surgical
site infection (n=6) and fever (n=8). Preoperative blood transfusion
rate was 9.07±1.92. Blood transfusion requirement rates were
also drastically reduced to 0.5±0.707 postsplenectomy in these
patients (p-value<0.001).
Conclusion: Following splenectomy, the need of blood
transfusion was grossly reduced and also, the incidence of its
complication was reduced. |
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| ISSN: | 2249-782X 0973-709X |