Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study
Introduction: Sickle Cell Disease (SCD) is a common haemoglobinopathy, where spleen is considered to be the first organ to be involved. Although it initially undergoes enlargement, but most often there occurs autosplenectomy. But in some cases, there is persistence of splenomegaly which may be a...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17029/57815_CE(AD)_F[SH]_PF1(AG_SS)_PFA(SS)_PB(AG_SS)_PN(SS).pdf |
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| author | Abinash Kumar Panda Bhupati Bhusan Das B Swagat Kumar Subudhi Indrajeet Padhy |
| author_facet | Abinash Kumar Panda Bhupati Bhusan Das B Swagat Kumar Subudhi Indrajeet Padhy |
| author_sort | Abinash Kumar Panda |
| collection | DOAJ |
| description | Introduction: Sickle Cell Disease (SCD) is a common
haemoglobinopathy, where spleen is considered to be the first
organ to be involved. Although it initially undergoes enlargement,
but most often there occurs autosplenectomy. But in some cases,
there is persistence of splenomegaly which may be associated
with various complications. In these situations, splenectomy is
considered as a good option to mitigate all these morbidities.
Aim: To analyse the effect of splenectomy on haematological
parameters and complications in patients of SCD in postoperative
period.
Materials and Methods: This was a retrospective study
conducted at SLN Medical College and Hospital, Koraput,
Odisha, India, from April 2019 to March 2021. Total 42 patients
of SCD underwent splenectomy. The haematological parameters
{Haemoglobin (Hb), Total Leukocyte Count (TLC) and Total Platelet Count (TPC)} and blood transfusion needs were compared in
preoperative and postoperative periods and analysed statistically
with Student’s t-test.
Results: Primary indication of splenectomy was hypersplenism
31 (73.8%) followed by splenic sequestration crisis in 8
patients (19.05%) and splenic abscess in 3 patients (7.1%).
Postsplenectomy haemoglobin improvement was around 5.17
gm% (p-value<0.001). Postoperative complication was also
minimal, seen in only eight patients, it was mostly due to surgical
site infection (n=6) and fever (n=8). Preoperative blood transfusion
rate was 9.07±1.92. Blood transfusion requirement rates were
also drastically reduced to 0.5±0.707 postsplenectomy in these
patients (p-value<0.001).
Conclusion: Following splenectomy, the need of blood
transfusion was grossly reduced and also, the incidence of its
complication was reduced. |
| first_indexed | 2024-04-10T22:23:51Z |
| format | Article |
| id | doaj.art-247b8ef7fe194819888339d3c923263c |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T22:23:51Z |
| publishDate | 2022-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-247b8ef7fe194819888339d3c923263c2023-01-17T11:02:45ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-10-011610PC16PC1910.7860/JCDR/2022/57815.17029Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective StudyAbinash Kumar Panda0Bhupati Bhusan Das1B Swagat Kumar Subudhi2Indrajeet Padhy3Assistant Professor, Department of Paediatric Surgery, SCB Medical College, Cuttack, Odisha, India.Associate Professor, Department of General Surgery, SLN Medical College, Koraput, Odisha, India.Assistant Professor, Department of General Surgery, SLN Medical College, Koraput, Odisha, India.Senior Resident, Department of General Surgery, SLN Medical College, Koraput, Odisha, India.Introduction: Sickle Cell Disease (SCD) is a common haemoglobinopathy, where spleen is considered to be the first organ to be involved. Although it initially undergoes enlargement, but most often there occurs autosplenectomy. But in some cases, there is persistence of splenomegaly which may be associated with various complications. In these situations, splenectomy is considered as a good option to mitigate all these morbidities. Aim: To analyse the effect of splenectomy on haematological parameters and complications in patients of SCD in postoperative period. Materials and Methods: This was a retrospective study conducted at SLN Medical College and Hospital, Koraput, Odisha, India, from April 2019 to March 2021. Total 42 patients of SCD underwent splenectomy. The haematological parameters {Haemoglobin (Hb), Total Leukocyte Count (TLC) and Total Platelet Count (TPC)} and blood transfusion needs were compared in preoperative and postoperative periods and analysed statistically with Student’s t-test. Results: Primary indication of splenectomy was hypersplenism 31 (73.8%) followed by splenic sequestration crisis in 8 patients (19.05%) and splenic abscess in 3 patients (7.1%). Postsplenectomy haemoglobin improvement was around 5.17 gm% (p-value<0.001). Postoperative complication was also minimal, seen in only eight patients, it was mostly due to surgical site infection (n=6) and fever (n=8). Preoperative blood transfusion rate was 9.07±1.92. Blood transfusion requirement rates were also drastically reduced to 0.5±0.707 postsplenectomy in these patients (p-value<0.001). Conclusion: Following splenectomy, the need of blood transfusion was grossly reduced and also, the incidence of its complication was reduced.https://jcdr.net/articles/PDF/17029/57815_CE(AD)_F[SH]_PF1(AG_SS)_PFA(SS)_PB(AG_SS)_PN(SS).pdfhypersplenismsickle cell diseasessplenomegaly |
| spellingShingle | Abinash Kumar Panda Bhupati Bhusan Das B Swagat Kumar Subudhi Indrajeet Padhy Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study Journal of Clinical and Diagnostic Research hypersplenism sickle cell diseases splenomegaly |
| title | Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study |
| title_full | Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study |
| title_fullStr | Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study |
| title_full_unstemmed | Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study |
| title_short | Splenectomy in Sickle Cell Haemoglobinopathies from a Tertiary Hospital of Southern Odisha: A Retrospective Study |
| title_sort | splenectomy in sickle cell haemoglobinopathies from a tertiary hospital of southern odisha a retrospective study |
| topic | hypersplenism sickle cell diseases splenomegaly |
| url | https://jcdr.net/articles/PDF/17029/57815_CE(AD)_F[SH]_PF1(AG_SS)_PFA(SS)_PB(AG_SS)_PN(SS).pdf |
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