HIF-1 and NRF2; Key Molecules for Malignant Phenotypes of Pancreatic Cancer

HIF-1 and NRF2; Key Molecules for Malignant Phenotypes of Pancreatic Cancer

Pancreatic cancer is intractable due to early progression and resistance to conventional therapy. Dense fibrotic stroma, known as desmoplasia, is a characteristic feature of pancreatic cancer, and develops through the interactions between pancreatic cancer cells and stromal cells, including pancreat...

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Bibliographic Details
Main Authors: Shin Hamada, Ryotaro Matsumoto, Atsushi Masamune
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
HIF-1
KEAP1
NRF2
hypoxia
microenvironment
oxidative stress
Online Access:https://www.mdpi.com/2072-6694/14/2/411

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