Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity
Gioblastoma tumours consist of different niches defined by histology. Here, the authors use proteomics and machine learning to assign protein expression programs to these niches, and reveal that KRAS and hypoxia are associated with drug resistance.
Bibliographic Details
| Main Authors: |
K. H. Brian Lam,
Alberto J. Leon,
Weili Hui,
Sandy Che-Eun Lee,
Ihor Batruch,
Kevin Faust,
Almos Klekner,
Gábor Hutóczki,
Marianne Koritzinsky,
Maxime Richer,
Ugljesa Djuric,
Phedias Diamandis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27667-w
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