Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva
Objective: The accurate assessment of the involvement of mandibular gingival squamous cell carcinoma (SCC) is essential for determining the extent of resection and is also useful for predicting lymph node metastasis and prognosis. The purpose of this study was to investigate the factors for predicti...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023103288 |
| _version_ | 1797337077441888256 |
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| author | Hirofumi Tomioka Naoto Nishii Yu Oikawa Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Kou Kayamori Atsushi Kaida Masahiko Miura Hiroyuki Harada |
| author_facet | Hirofumi Tomioka Naoto Nishii Yu Oikawa Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Kou Kayamori Atsushi Kaida Masahiko Miura Hiroyuki Harada |
| author_sort | Hirofumi Tomioka |
| collection | DOAJ |
| description | Objective: The accurate assessment of the involvement of mandibular gingival squamous cell carcinoma (SCC) is essential for determining the extent of resection and is also useful for predicting lymph node metastasis and prognosis. The purpose of this study was to investigate the factors for predicting the prognosis. Study design: We reviewed 134 patients with mandibular gingival SCC treated between 2008 and 2017. The clinical findings, TN stage, relationship between radiographical type and histological pattern, and factors affecting the survival rate were investigated. Results: The moth-eaten radiographic type was significantly associated with histologically infiltrative pattern. For all 134 cases, the 5-year OS was 89.5 %, and 5-year DSS was 93.9 %. The 5-year DSS was 95.0 % for cN0 and/or pN0 cases and 90.3 % for pN (+) cases, with a significant difference. The significant risk factors for lymph node metastasis were teeth extractions by previous physicians and moth-eaten radiographic type. Conclusion: The risk factor for poor prognosis was lymph node metastasis. In addition, teeth extractions by previous physicians and moth-eaten radiographic type were the risk factors for lymph node metastasis. It is recommended that these cases be treated considering the possibility of cervical lymph node metastasis. |
| first_indexed | 2024-03-08T09:04:11Z |
| format | Article |
| id | doaj.art-24809d91f35640c18cfe42e5232958c8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:04:11Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-24809d91f35640c18cfe42e5232958c82024-02-01T06:30:48ZengElsevierHeliyon2405-84402024-01-01101e23120Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingivaHirofumi Tomioka0Naoto Nishii1Yu Oikawa2Takuma Kugimoto3Takeshi Kuroshima4Hideaki Hirai5Kou Kayamori6Atsushi Kaida7Masahiko Miura8Hiroyuki Harada9Department of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan; Corresponding author. 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.Department of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral Pathology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Dental Radiology and Radiation Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Dental Radiology and Radiation Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanObjective: The accurate assessment of the involvement of mandibular gingival squamous cell carcinoma (SCC) is essential for determining the extent of resection and is also useful for predicting lymph node metastasis and prognosis. The purpose of this study was to investigate the factors for predicting the prognosis. Study design: We reviewed 134 patients with mandibular gingival SCC treated between 2008 and 2017. The clinical findings, TN stage, relationship between radiographical type and histological pattern, and factors affecting the survival rate were investigated. Results: The moth-eaten radiographic type was significantly associated with histologically infiltrative pattern. For all 134 cases, the 5-year OS was 89.5 %, and 5-year DSS was 93.9 %. The 5-year DSS was 95.0 % for cN0 and/or pN0 cases and 90.3 % for pN (+) cases, with a significant difference. The significant risk factors for lymph node metastasis were teeth extractions by previous physicians and moth-eaten radiographic type. Conclusion: The risk factor for poor prognosis was lymph node metastasis. In addition, teeth extractions by previous physicians and moth-eaten radiographic type were the risk factors for lymph node metastasis. It is recommended that these cases be treated considering the possibility of cervical lymph node metastasis.http://www.sciencedirect.com/science/article/pii/S2405844023103288Squamous cell carcinomaOral cancerMandibular gingivaRisk factor |
| spellingShingle | Hirofumi Tomioka Naoto Nishii Yu Oikawa Takuma Kugimoto Takeshi Kuroshima Hideaki Hirai Kou Kayamori Atsushi Kaida Masahiko Miura Hiroyuki Harada Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva Heliyon Squamous cell carcinoma Oral cancer Mandibular gingiva Risk factor |
| title | Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| title_full | Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| title_fullStr | Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| title_full_unstemmed | Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| title_short | Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| title_sort | clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva |
| topic | Squamous cell carcinoma Oral cancer Mandibular gingiva Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023103288 |
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