Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

DEB025 (alisporivir) is a synthetic cyclosporine with inhibitory activity against human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV). It binds to cyclophilin A (CypA) and blocks essential functions of CypA in the viral replication cycles of both viruses. DEB025 inhibits clinical...

Full description

Bibliographic Details
Main Authors: Brigitte Rosenwirth, Jean-Maurice Dumont, Grégoire Vuagniaux, Michael D. Bobardt, Philippe A. Gallay, Roger G. Ptak
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Viruses
Subjects:
DEB025
alisporivir
cyclophilin inhibitors
cyclosporines
HIV/retroviruses
HIV capsid
natural resistance
Online Access:http://www.mdpi.com/1999-4915/5/3/981

Similar Items

Similar Items