The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

Oncocytomas are predominantly benign neoplasms possessing pathogenic mitochondrial mutations and accumulation of respiration-defective mitochondria, characteristics of unknown significance. Using exome and transcriptome sequencing, we identified two main subtypes of renal oncocytoma. Type 1 is diplo...

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Bibliographic Details
Main Authors: Shilpy Joshi, Denis Tolkunov, Hana Aviv, Abraham A. Hakimi, Ming Yao, James J. Hsieh, Shridar Ganesan, Chang S. Chan, Eileen White
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
oncocytoma
cancer metabolism
mitochondria
cancer genomics
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012486

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