Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype

Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype

The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and defects in mitochondrial oxidative metabolism...

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Bibliographic Details
Main Authors: Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial ATP generation
mitochondrial dysfunction
vascular smooth muscle cells
oxidative metabolism
glycolysis
Online Access:https://www.mdpi.com/1422-0067/23/1/217

Internet

https://www.mdpi.com/1422-0067/23/1/217

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