TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666, and RNAi to determ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3522609?pdf=render |
| _version_ | 1818113920486866944 |
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| author | María Ll Valero Fernanda Mello de Queiroz Walter Stühmer Félix Viana Luis A Pardo |
| author_facet | María Ll Valero Fernanda Mello de Queiroz Walter Stühmer Félix Viana Luis A Pardo |
| author_sort | María Ll Valero |
| collection | DOAJ |
| description | Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666, and RNAi to determine the relevance of TRPM8 expression in the proliferation of non-tumor and tumor cells. Inhibition of the expression or function of the channel reduces proliferation rates and proliferative fraction in all tumor cells tested, but not of non-tumor prostate cells. We observed no consistent acceleration of growth after stimulation of the channel with menthol or icilin, indicating that basal TRPM8 expression is enough to sustain growth of prostate cancer cells. |
| first_indexed | 2024-12-11T03:42:30Z |
| format | Article |
| id | doaj.art-24849c1e8c6b48b8985b29ccd48a82ad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T03:42:30Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-24849c1e8c6b48b8985b29ccd48a82ad2022-12-22T01:22:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5182510.1371/journal.pone.0051825TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.María Ll ValeroFernanda Mello de QueirozWalter StühmerFélix VianaLuis A PardoOverexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666, and RNAi to determine the relevance of TRPM8 expression in the proliferation of non-tumor and tumor cells. Inhibition of the expression or function of the channel reduces proliferation rates and proliferative fraction in all tumor cells tested, but not of non-tumor prostate cells. We observed no consistent acceleration of growth after stimulation of the channel with menthol or icilin, indicating that basal TRPM8 expression is enough to sustain growth of prostate cancer cells.http://europepmc.org/articles/PMC3522609?pdf=render |
| spellingShingle | María Ll Valero Fernanda Mello de Queiroz Walter Stühmer Félix Viana Luis A Pardo TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. PLoS ONE |
| title | TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. |
| title_full | TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. |
| title_fullStr | TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. |
| title_full_unstemmed | TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. |
| title_short | TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. |
| title_sort | trpm8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells |
| url | http://europepmc.org/articles/PMC3522609?pdf=render |
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