Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)
Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GRE...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578920301028 |
| _version_ | 1819142976142573568 |
|---|---|
| author | Whitney R. Grither Brendan C. Dickson Katherine C. Fuh Ian S. Hagemann |
| author_facet | Whitney R. Grither Brendan C. Dickson Katherine C. Fuh Ian S. Hagemann |
| author_sort | Whitney R. Grither |
| collection | DOAJ |
| description | Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses. |
| first_indexed | 2024-12-22T12:18:54Z |
| format | Article |
| id | doaj.art-248534f0c0484208b6ea2f71f33545dc |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-22T12:18:54Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-248534f0c0484208b6ea2f71f33545dc2022-12-21T18:26:03ZengElsevierGynecologic Oncology Reports2352-57892020-11-0134100636Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)Whitney R. Grither0Brendan C. Dickson1Katherine C. Fuh2Ian S. Hagemann3Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USADepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, CanadaDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USADepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Corresponding author at: 425 S. Euclid Ave., Campus Box 8118, St. Louis, MO 63110, USA.Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.http://www.sciencedirect.com/science/article/pii/S2352578920301028Uterine tumor resembling ovarian sex cord tumorRNA-sequencingFusion geneUterine tumorsPathology |
| spellingShingle | Whitney R. Grither Brendan C. Dickson Katherine C. Fuh Ian S. Hagemann Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) Gynecologic Oncology Reports Uterine tumor resembling ovarian sex cord tumor RNA-sequencing Fusion gene Uterine tumors Pathology |
| title | Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) |
| title_full | Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) |
| title_fullStr | Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) |
| title_full_unstemmed | Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) |
| title_short | Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT) |
| title_sort | detection of a somatic greb1 ncoa1 gene fusion in a uterine tumor resembling ovarian sex cord tumor utrosct |
| topic | Uterine tumor resembling ovarian sex cord tumor RNA-sequencing Fusion gene Uterine tumors Pathology |
| url | http://www.sciencedirect.com/science/article/pii/S2352578920301028 |
| work_keys_str_mv | AT whitneyrgrither detectionofasomaticgreb1ncoa1genefusioninauterinetumorresemblingovariansexcordtumorutrosct AT brendancdickson detectionofasomaticgreb1ncoa1genefusioninauterinetumorresemblingovariansexcordtumorutrosct AT katherinecfuh detectionofasomaticgreb1ncoa1genefusioninauterinetumorresemblingovariansexcordtumorutrosct AT ianshagemann detectionofasomaticgreb1ncoa1genefusioninauterinetumorresemblingovariansexcordtumorutrosct |