Leukocyte count: A reliable marker for the severity of organophosphate intoxication?
INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-04-01
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| Series: | Journal of Laboratory Physicians |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/JLP.JLP_100_17 |
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| author | Sunil Kumar Sachin Agrawal Nitin Raisinghani Shameem Khan |
| author_facet | Sunil Kumar Sachin Agrawal Nitin Raisinghani Shameem Khan |
| author_sort | Sunil Kumar |
| collection | DOAJ |
| description | INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis.
MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale.
RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP.
CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning. |
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| id | doaj.art-24874ce949d24a6f8bfaa100acf0e1b6 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-12-12T17:03:34Z |
| publishDate | 2018-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-24874ce949d24a6f8bfaa100acf0e1b62022-12-22T00:18:04ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262018-04-01100218518810.4103/JLP.JLP_100_17Leukocyte count: A reliable marker for the severity of organophosphate intoxication?Sunil Kumar0Sachin Agrawal1Nitin Raisinghani2Shameem Khan3Department of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, IndiaDepartment of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, IndiaDepartment of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, IndiaDepartment of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, IndiaINTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis. MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale. RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP. CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning.http://www.thieme-connect.de/DOI/DOI?10.4103/JLP.JLP_100_17correlationleukocyte countorganophosphorusplasma cholinesterasepoisoningseverity |
| spellingShingle | Sunil Kumar Sachin Agrawal Nitin Raisinghani Shameem Khan Leukocyte count: A reliable marker for the severity of organophosphate intoxication? Journal of Laboratory Physicians correlation leukocyte count organophosphorus plasma cholinesterase poisoning severity |
| title | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
| title_full | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
| title_fullStr | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
| title_full_unstemmed | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
| title_short | Leukocyte count: A reliable marker for the severity of organophosphate intoxication? |
| title_sort | leukocyte count a reliable marker for the severity of organophosphate intoxication |
| topic | correlation leukocyte count organophosphorus plasma cholinesterase poisoning severity |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/JLP.JLP_100_17 |
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