A CRISPR Screen of HIV Dependency Factors Reveals That <i>CCNT1</i> Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

A CRISPR Screen of HIV Dependency Factors Reveals That <i>CCNT1</i> Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency reactivation. We identified several HIV-1 dependency...

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Bibliographic Details
Main Authors: Terry L. Hafer, Abby Felton, Yennifer Delgado, Harini Srinivasan, Michael Emerman
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Viruses
Subjects:
HIV latency
dependency factors
P-TEFb complex
latency reversal agent (LRA)
CRISPR screening
Cyclin T1
Online Access:https://www.mdpi.com/1999-4915/15/9/1863

Internet

https://www.mdpi.com/1999-4915/15/9/1863

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