New insight on microglia activation in neurodegenerative diseases and therapeutics
Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In response to changes in the surrounding environment, microglia activate and change their state and function. Several...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1308345/full |
| _version_ | 1797382972823830528 |
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| author | Yucong Xu Yucong Xu Wei Gao Wei Gao Yingnan Sun Minghua Wu Minghua Wu |
| author_facet | Yucong Xu Yucong Xu Wei Gao Wei Gao Yingnan Sun Minghua Wu Minghua Wu |
| author_sort | Yucong Xu |
| collection | DOAJ |
| description | Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In response to changes in the surrounding environment, microglia activate and change their state and function. Several factors, example for circadian rhythm disruption and the development of neurodegenerative diseases, influence microglia activation. In this review, we explore microglia’s function and the associated neural mechanisms. We elucidate that circadian rhythms are essential factors influencing microglia activation and function. Circadian rhythm disruption affects microglia activation and, consequently, neurodegenerative diseases. In addition, we found that abnormal microglia activation is a common feature of neurodegenerative diseases and an essential factor of disease development. Here we highlight the importance of microglia activation in neurodegenerative diseases. Targeting microglia for neurodegenerative disease treatment is a promising direction. We introduce the progress of methods targeting microglia for the treatment of neurodegenerative diseases and summarize the progress of drugs developed with microglia as targets, hoping to provide new ideas for treating neurodegenerative diseases. |
| first_indexed | 2024-03-08T21:14:02Z |
| format | Article |
| id | doaj.art-2489395a53a14ef9bdc9ba4d0e18cca5 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T21:14:02Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2489395a53a14ef9bdc9ba4d0e18cca52023-12-22T04:13:57ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-12-011710.3389/fnins.2023.13083451308345New insight on microglia activation in neurodegenerative diseases and therapeuticsYucong Xu0Yucong Xu1Wei Gao2Wei Gao3Yingnan Sun4Minghua Wu5Minghua Wu6Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, ChinaHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, ChinaHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, ChinaMicroglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In response to changes in the surrounding environment, microglia activate and change their state and function. Several factors, example for circadian rhythm disruption and the development of neurodegenerative diseases, influence microglia activation. In this review, we explore microglia’s function and the associated neural mechanisms. We elucidate that circadian rhythms are essential factors influencing microglia activation and function. Circadian rhythm disruption affects microglia activation and, consequently, neurodegenerative diseases. In addition, we found that abnormal microglia activation is a common feature of neurodegenerative diseases and an essential factor of disease development. Here we highlight the importance of microglia activation in neurodegenerative diseases. Targeting microglia for neurodegenerative disease treatment is a promising direction. We introduce the progress of methods targeting microglia for the treatment of neurodegenerative diseases and summarize the progress of drugs developed with microglia as targets, hoping to provide new ideas for treating neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fnins.2023.1308345/fullmicrogliacentral nervous systemneurodegenerative diseasescircadian rhythmsdrug targetstherapeutic approaches |
| spellingShingle | Yucong Xu Yucong Xu Wei Gao Wei Gao Yingnan Sun Minghua Wu Minghua Wu New insight on microglia activation in neurodegenerative diseases and therapeutics Frontiers in Neuroscience microglia central nervous system neurodegenerative diseases circadian rhythms drug targets therapeutic approaches |
| title | New insight on microglia activation in neurodegenerative diseases and therapeutics |
| title_full | New insight on microglia activation in neurodegenerative diseases and therapeutics |
| title_fullStr | New insight on microglia activation in neurodegenerative diseases and therapeutics |
| title_full_unstemmed | New insight on microglia activation in neurodegenerative diseases and therapeutics |
| title_short | New insight on microglia activation in neurodegenerative diseases and therapeutics |
| title_sort | new insight on microglia activation in neurodegenerative diseases and therapeutics |
| topic | microglia central nervous system neurodegenerative diseases circadian rhythms drug targets therapeutic approaches |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1308345/full |
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