Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks
ABSTRACT: Like glucose, fructose is a monosaccharide, but the mechanisms of its absorption and metabolism in the body are very different between the 2 molecules. In this study, we investigated the effects of oral administration of glucose and fructose on food intake, diencephalic gene expression, an...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579122005454 |
| _version_ | 1811244255594676224 |
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| author | Yoshimitsu Ouchi Yoshinori Komaki Kensuke Shimizu Natsuki Fukano Toshihisa Sugino Jun-ichi Shiraishi Vishwajit S. Chowdhury Takashi Bungo |
| author_facet | Yoshimitsu Ouchi Yoshinori Komaki Kensuke Shimizu Natsuki Fukano Toshihisa Sugino Jun-ichi Shiraishi Vishwajit S. Chowdhury Takashi Bungo |
| author_sort | Yoshimitsu Ouchi |
| collection | DOAJ |
| description | ABSTRACT: Like glucose, fructose is a monosaccharide, but the mechanisms of its absorption and metabolism in the body are very different between the 2 molecules. In this study, we investigated the effects of oral administration of glucose and fructose on food intake, diencephalic gene expression, and plasma metabolite concentrations in broiler chicks. The animals used in this study were 4-day-old male broiler chicks (Ross 308). They were given glucose, fructose (200 mg/ 0.5 mL/ bird), or a similar volume of distilled water orally after 6 h fasting. After treatment, measurements of food intake (at 0, 30, and 60 min), and blood glucose as well as insulin concentrations were measured over time; however, diencephalic (hypothalamus) gene expression and plasma metabolites were measured at 30 min. The results showed that glucose administration suppressed food intake, but fructose administration did not suppress food intake and it was at the same level as distilled water administration. In addition, fructose administration did not increase plasma glucose and insulin levels as did glucose administration. In the diencephalon, expression levels of genes related to the melanocortin system were unaffected by the treatment, while gene expression levels related to intracellular energy regulation, such as AMP-activated protein kinase were affected by the glucose treatment in the fasted chicks. These results suggest that fructose administration does not suppress feeding behavior as a result of possible reduction in the energy levels in the diencephalon and associated energy metabolism. |
| first_indexed | 2024-04-12T14:22:46Z |
| format | Article |
| id | doaj.art-248a5be415304b498df19e2f34f0823a |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-04-12T14:22:46Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-248a5be415304b498df19e2f34f0823a2022-12-22T03:29:31ZengElsevierPoultry Science0032-57912023-01-011021102249Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicksYoshimitsu Ouchi0Yoshinori Komaki1Kensuke Shimizu2Natsuki Fukano3Toshihisa Sugino4Jun-ichi Shiraishi5Vishwajit S. Chowdhury6Takashi Bungo7Faculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, JapanGraduate School of Bioresource Science, Hiroshima University, Higashi-Hiroshima 739-8528, JapanGraduate School of Bioresource Science, Hiroshima University, Higashi-Hiroshima 739-8528, JapanGraduate School of Bioresource Science, Hiroshima University, Higashi-Hiroshima 739-8528, JapanGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8528, JapanDepartment of Animal Science, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanFaculty of Arts and Science, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 819-0395, JapanFaculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Japan; Corresponding author:ABSTRACT: Like glucose, fructose is a monosaccharide, but the mechanisms of its absorption and metabolism in the body are very different between the 2 molecules. In this study, we investigated the effects of oral administration of glucose and fructose on food intake, diencephalic gene expression, and plasma metabolite concentrations in broiler chicks. The animals used in this study were 4-day-old male broiler chicks (Ross 308). They were given glucose, fructose (200 mg/ 0.5 mL/ bird), or a similar volume of distilled water orally after 6 h fasting. After treatment, measurements of food intake (at 0, 30, and 60 min), and blood glucose as well as insulin concentrations were measured over time; however, diencephalic (hypothalamus) gene expression and plasma metabolites were measured at 30 min. The results showed that glucose administration suppressed food intake, but fructose administration did not suppress food intake and it was at the same level as distilled water administration. In addition, fructose administration did not increase plasma glucose and insulin levels as did glucose administration. In the diencephalon, expression levels of genes related to the melanocortin system were unaffected by the treatment, while gene expression levels related to intracellular energy regulation, such as AMP-activated protein kinase were affected by the glucose treatment in the fasted chicks. These results suggest that fructose administration does not suppress feeding behavior as a result of possible reduction in the energy levels in the diencephalon and associated energy metabolism.http://www.sciencedirect.com/science/article/pii/S0032579122005454monosaccharideschickfood intakegene expressioninsulin |
| spellingShingle | Yoshimitsu Ouchi Yoshinori Komaki Kensuke Shimizu Natsuki Fukano Toshihisa Sugino Jun-ichi Shiraishi Vishwajit S. Chowdhury Takashi Bungo Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks Poultry Science monosaccharides chick food intake gene expression insulin |
| title | Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| title_full | Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| title_fullStr | Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| title_full_unstemmed | Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| title_short | Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| title_sort | comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks |
| topic | monosaccharides chick food intake gene expression insulin |
| url | http://www.sciencedirect.com/science/article/pii/S0032579122005454 |
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