USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc

USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc

Abstract Background c-Myc, a well-established oncogene, plays an important role in the initiation and progression of various cancers, including prostate cancer. However, its mechanism in cancer cell remains largely unknown and whether there exist a deubiquitinase targeting c-Myc also remains elusive...

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Bibliographic Details
Main Authors: Jianchao Ge, Wandong Yu, Junhong Li, Hangbin Ma, Pengyu Wang, Yinghao Zhou, Yang Wang, Jun Zhang, Guowei Shi
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
USP16
C-Myc
Deubiquitinase
Prostate cancer
Online Access:https://doi.org/10.1186/s13046-021-01843-8

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