3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects
3D Single-breath Chemical Shift Imaging (3D-SBCSI) is a hybrid MR-spectroscopic imaging modality that uses hyperpolarized xenon-129 gas (Xe-129) to differentiate lung diseases by probing functional characteristics. This study tests the efficacy of 3D-SBCSI in differentiating physiology among pulmona...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Tomography |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2379-139X/8/5/215 |
| _version_ | 1797469751619878912 |
|---|---|
| author | Steven Guan Nick Tustison Kun Qing Yun Michael Shim John Mugler Talissa Altes Dana Albon Deborah Froh Borna Mehrad James Patrie Alan Ropp Braden Miller Jill Nehrbas Jaime Mata |
| author_facet | Steven Guan Nick Tustison Kun Qing Yun Michael Shim John Mugler Talissa Altes Dana Albon Deborah Froh Borna Mehrad James Patrie Alan Ropp Braden Miller Jill Nehrbas Jaime Mata |
| author_sort | Steven Guan |
| collection | DOAJ |
| description | 3D Single-breath Chemical Shift Imaging (3D-SBCSI) is a hybrid MR-spectroscopic imaging modality that uses hyperpolarized xenon-129 gas (Xe-129) to differentiate lung diseases by probing functional characteristics. This study tests the efficacy of 3D-SBCSI in differentiating physiology among pulmonary diseases. A total of 45 subjects—16 healthy, 11 idiopathic pulmonary fibrosis (IPF), 13 cystic fibrosis (CF), and 5 chronic obstructive pulmonary disease (COPD)—were given 1/3 forced vital capacity (FVC) of hyperpolarized Xe-129, inhaled for a ~7 s MRI acquisition. Proton, Xe-129 ventilation, and 3D-SBCSI images were acquired with separate breath-holds using a radiofrequency chest coil tuned to Xe-129. The Xe-129 spectrum was analyzed in each lung voxel for ratios of spectroscopic peaks, chemical shifts, and T2* relaxation. CF and COPD subjects had significantly more ventilation defects than IPF and healthy subjects, which correlated with FEV1 predicted (R = −0.74). FEV1 predicted correlated well with RBC/Gas ratio (R = 0.67). COPD and IPF had significantly higher Tissue/RBC ratios than other subjects, longer RBC T2* relaxation times, and greater RBC chemical shifts. CF subjects had more ventilation defects than healthy subjects, elevated Tissue/RBC ratio, shorter Tissue T2* relaxation, and greater RBC chemical shift. 3D-SBCSI may be helpful in the detection and characterization of pulmonary disease, following treatment efficacy, and predicting disease outcomes. |
| first_indexed | 2024-03-09T19:25:36Z |
| format | Article |
| id | doaj.art-248f344f6b8643a1995f95e0718dca1d |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-09T19:25:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-248f344f6b8643a1995f95e0718dca1d2023-11-24T02:56:46ZengMDPI AGTomography2379-13812379-139X2022-10-01852574258710.3390/tomography80502153D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD SubjectsSteven Guan0Nick Tustison1Kun Qing2Yun Michael Shim3John Mugler4Talissa Altes5Dana Albon6Deborah Froh7Borna Mehrad8James Patrie9Alan Ropp10Braden Miller11Jill Nehrbas12Jaime Mata13Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiation Oncology, City of Hope, Duarte, CA 91010, USADepartment of Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Medicine, University of Florida, Gainesville, FL 32611, USADepartment of Public Health, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USADepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA3D Single-breath Chemical Shift Imaging (3D-SBCSI) is a hybrid MR-spectroscopic imaging modality that uses hyperpolarized xenon-129 gas (Xe-129) to differentiate lung diseases by probing functional characteristics. This study tests the efficacy of 3D-SBCSI in differentiating physiology among pulmonary diseases. A total of 45 subjects—16 healthy, 11 idiopathic pulmonary fibrosis (IPF), 13 cystic fibrosis (CF), and 5 chronic obstructive pulmonary disease (COPD)—were given 1/3 forced vital capacity (FVC) of hyperpolarized Xe-129, inhaled for a ~7 s MRI acquisition. Proton, Xe-129 ventilation, and 3D-SBCSI images were acquired with separate breath-holds using a radiofrequency chest coil tuned to Xe-129. The Xe-129 spectrum was analyzed in each lung voxel for ratios of spectroscopic peaks, chemical shifts, and T2* relaxation. CF and COPD subjects had significantly more ventilation defects than IPF and healthy subjects, which correlated with FEV1 predicted (R = −0.74). FEV1 predicted correlated well with RBC/Gas ratio (R = 0.67). COPD and IPF had significantly higher Tissue/RBC ratios than other subjects, longer RBC T2* relaxation times, and greater RBC chemical shifts. CF subjects had more ventilation defects than healthy subjects, elevated Tissue/RBC ratio, shorter Tissue T2* relaxation, and greater RBC chemical shift. 3D-SBCSI may be helpful in the detection and characterization of pulmonary disease, following treatment efficacy, and predicting disease outcomes.https://www.mdpi.com/2379-139X/8/5/215hyperpolarized xenon-129MRICOPDcystic fibrosisidiopathic pulmonary fibrosis |
| spellingShingle | Steven Guan Nick Tustison Kun Qing Yun Michael Shim John Mugler Talissa Altes Dana Albon Deborah Froh Borna Mehrad James Patrie Alan Ropp Braden Miller Jill Nehrbas Jaime Mata 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects Tomography hyperpolarized xenon-129 MRI COPD cystic fibrosis idiopathic pulmonary fibrosis |
| title | 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects |
| title_full | 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects |
| title_fullStr | 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects |
| title_full_unstemmed | 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects |
| title_short | 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects |
| title_sort | 3d single breath chemical shift imaging hyperpolarized xe 129 mri of healthy cf ipf and copd subjects |
| topic | hyperpolarized xenon-129 MRI COPD cystic fibrosis idiopathic pulmonary fibrosis |
| url | https://www.mdpi.com/2379-139X/8/5/215 |
| work_keys_str_mv | AT stevenguan 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT nicktustison 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT kunqing 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT yunmichaelshim 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT johnmugler 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT talissaaltes 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT danaalbon 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT deborahfroh 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT bornamehrad 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT jamespatrie 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT alanropp 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT bradenmiller 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT jillnehrbas 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects AT jaimemata 3dsinglebreathchemicalshiftimaginghyperpolarizedxe129mriofhealthycfipfandcopdsubjects |