Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-reaching concept of selective Gα agonism.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31652-2 |
| _version_ | 1818509934830026752 |
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| author | Mark J. Wall Emily Hill Robert Huckstepp Kerry Barkan Giuseppe Deganutti Michele Leuenberger Barbara Preti Ian Winfield Sabrina Carvalho Anna Suchankova Haifeng Wei Dewi Safitri Xianglin Huang Wendy Imlach Circe La Mache Eve Dean Cherise Hume Stephanie Hayward Jess Oliver Fei-Yue Zhao David Spanswick Christopher A. Reynolds Martin Lochner Graham Ladds Bruno G. Frenguelli |
| author_facet | Mark J. Wall Emily Hill Robert Huckstepp Kerry Barkan Giuseppe Deganutti Michele Leuenberger Barbara Preti Ian Winfield Sabrina Carvalho Anna Suchankova Haifeng Wei Dewi Safitri Xianglin Huang Wendy Imlach Circe La Mache Eve Dean Cherise Hume Stephanie Hayward Jess Oliver Fei-Yue Zhao David Spanswick Christopher A. Reynolds Martin Lochner Graham Ladds Bruno G. Frenguelli |
| author_sort | Mark J. Wall |
| collection | DOAJ |
| description | Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-reaching concept of selective Gα agonism. |
| first_indexed | 2024-12-10T22:52:18Z |
| format | Article |
| id | doaj.art-248fd0638f5942beb0219612bf9fe670 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T22:52:18Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-248fd0638f5942beb0219612bf9fe6702022-12-22T01:30:22ZengNature PortfolioNature Communications2041-17232022-07-0113112210.1038/s41467-022-31652-2Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depressionMark J. Wall0Emily Hill1Robert Huckstepp2Kerry Barkan3Giuseppe Deganutti4Michele Leuenberger5Barbara Preti6Ian Winfield7Sabrina Carvalho8Anna Suchankova9Haifeng Wei10Dewi Safitri11Xianglin Huang12Wendy Imlach13Circe La Mache14Eve Dean15Cherise Hume16Stephanie Hayward17Jess Oliver18Fei-Yue Zhao19David Spanswick20Christopher A. Reynolds21Martin Lochner22Graham Ladds23Bruno G. Frenguelli24School of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickDepartment of Pharmacology, University of CambridgeCentre for Sport, Exercise and Life Sciences (CSELS), Faculty of Health and Life Sciences, Coventry UniversityInstitute of Biochemistry and Molecular Medicine, University of BernInstitute of Biochemistry and Molecular Medicine, University of BernDepartment of Pharmacology, University of CambridgeDepartment of Pharmacology, University of CambridgeDepartment of Pharmacology, University of CambridgeNeuroSolutions LtdDepartment of Pharmacology, University of CambridgeDepartment of Pharmacology, University of CambridgeDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash UniversitySchool of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickNeuroSolutions LtdNeuroSolutions LtdCentre for Sport, Exercise and Life Sciences (CSELS), Faculty of Health and Life Sciences, Coventry UniversityInstitute of Biochemistry and Molecular Medicine, University of BernDepartment of Pharmacology, University of CambridgeSchool of Life Sciences, University of WarwickWall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-reaching concept of selective Gα agonism.https://doi.org/10.1038/s41467-022-31652-2 |
| spellingShingle | Mark J. Wall Emily Hill Robert Huckstepp Kerry Barkan Giuseppe Deganutti Michele Leuenberger Barbara Preti Ian Winfield Sabrina Carvalho Anna Suchankova Haifeng Wei Dewi Safitri Xianglin Huang Wendy Imlach Circe La Mache Eve Dean Cherise Hume Stephanie Hayward Jess Oliver Fei-Yue Zhao David Spanswick Christopher A. Reynolds Martin Lochner Graham Ladds Bruno G. Frenguelli Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression Nature Communications |
| title | Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression |
| title_full | Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression |
| title_fullStr | Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression |
| title_full_unstemmed | Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression |
| title_short | Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression |
| title_sort | selective activation of gαob by an adenosine a1 receptor agonist elicits analgesia without cardiorespiratory depression |
| url | https://doi.org/10.1038/s41467-022-31652-2 |
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