Expression of Dopamine-Related Genes in Four Human Brain Regions
A better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National Institutes of Health’s Genotype-Tissue Expression project (GTEx) dataset to investigate genotype by expression associat...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/8/567 |
| _version_ | 1797557192313798656 |
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| author | Ansley Grimes Stanfill Xueyuan Cao |
| author_facet | Ansley Grimes Stanfill Xueyuan Cao |
| author_sort | Ansley Grimes Stanfill |
| collection | DOAJ |
| description | A better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National Institutes of Health’s Genotype-Tissue Expression project (GTEx) dataset to investigate genotype by expression associations in seven dopamine pathway genes (<i>ANKK1</i>, <i>DBH</i>, <i>DRD1</i>, <i>DRD2</i>, <i>DRD3</i>, <i>DRD5</i>, and <i>SLC6A3</i>) in and across four human brain tissues (prefrontal cortex, nucleus accumbens, substantia nigra, and hippocampus). We found that age alters expression of <i>DRD1</i> in the nucleus accumbens and prefrontal cortex, <i>DRD3</i> in the nucleus accumbens, and <i>DRD5</i> in the hippocampus and prefrontal cortex. Sex was associated with expression of <i>DRD5</i> in substantia nigra and hippocampus, and <i>SLC6A3</i> in substantia nigra. We found that three linkage disequilibrium blocks of SNPs, all located in <i>DRD2</i>, were associated with alterations in expression across all four tissues. These demographic characteristic associations and these variants should be further investigated for use in screening, diagnosis, and future treatment of neurological and psychiatric conditions. |
| first_indexed | 2024-03-10T17:13:52Z |
| format | Article |
| id | doaj.art-24924763fce44ad2b93499d4d2c105f6 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T17:13:52Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-24924763fce44ad2b93499d4d2c105f62023-11-20T10:33:42ZengMDPI AGBrain Sciences2076-34252020-08-0110856710.3390/brainsci10080567Expression of Dopamine-Related Genes in Four Human Brain RegionsAnsley Grimes Stanfill0Xueyuan Cao1Associate Professor and Associate Dean of Research, College of Nursing, University of Tennessee Health Science Center, Memphis, TN 38163, USAAssistant Professor, College of Nursing, University of Tennessee Health Science Center, Memphis, TN 38163, USAA better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National Institutes of Health’s Genotype-Tissue Expression project (GTEx) dataset to investigate genotype by expression associations in seven dopamine pathway genes (<i>ANKK1</i>, <i>DBH</i>, <i>DRD1</i>, <i>DRD2</i>, <i>DRD3</i>, <i>DRD5</i>, and <i>SLC6A3</i>) in and across four human brain tissues (prefrontal cortex, nucleus accumbens, substantia nigra, and hippocampus). We found that age alters expression of <i>DRD1</i> in the nucleus accumbens and prefrontal cortex, <i>DRD3</i> in the nucleus accumbens, and <i>DRD5</i> in the hippocampus and prefrontal cortex. Sex was associated with expression of <i>DRD5</i> in substantia nigra and hippocampus, and <i>SLC6A3</i> in substantia nigra. We found that three linkage disequilibrium blocks of SNPs, all located in <i>DRD2</i>, were associated with alterations in expression across all four tissues. These demographic characteristic associations and these variants should be further investigated for use in screening, diagnosis, and future treatment of neurological and psychiatric conditions.https://www.mdpi.com/2076-3425/10/8/567dopaminedopamine receptorsmesocorticalmesolimbicnigrostrialprefrontal cortex |
| spellingShingle | Ansley Grimes Stanfill Xueyuan Cao Expression of Dopamine-Related Genes in Four Human Brain Regions Brain Sciences dopamine dopamine receptors mesocortical mesolimbic nigrostrial prefrontal cortex |
| title | Expression of Dopamine-Related Genes in Four Human Brain Regions |
| title_full | Expression of Dopamine-Related Genes in Four Human Brain Regions |
| title_fullStr | Expression of Dopamine-Related Genes in Four Human Brain Regions |
| title_full_unstemmed | Expression of Dopamine-Related Genes in Four Human Brain Regions |
| title_short | Expression of Dopamine-Related Genes in Four Human Brain Regions |
| title_sort | expression of dopamine related genes in four human brain regions |
| topic | dopamine dopamine receptors mesocortical mesolimbic nigrostrial prefrontal cortex |
| url | https://www.mdpi.com/2076-3425/10/8/567 |
| work_keys_str_mv | AT ansleygrimesstanfill expressionofdopaminerelatedgenesinfourhumanbrainregions AT xueyuancao expressionofdopaminerelatedgenesinfourhumanbrainregions |