Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl<sub>4</sub> and TAA-Induced Liver Fibrosis in Mice

Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl<sub>4</sub> and TAA-Induced Liver Fibrosis in Mice

Persistent chronic liver diseases increase the scar formation and extracellular matrix accumulation that further progress to liver fibrosis and cirrhosis. Nevertheless, there is no antifibrotic therapy to date. The ketogenic diet is composed of high fat, moderate to low-protein, and very low carbohy...

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Bibliographic Details
Main Authors: Yi-Jen Liao, Yuan-Hsi Wang, Chien-Ying Wu, Fang-Yu Hsu, Chia-Ying Chien, Yi-Chieh Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat ketogenic diet
liver fibrosis
β-hydroxybutyrate
acetoacetate
hepatic stellate cells
Online Access:https://www.mdpi.com/1422-0067/22/6/2934

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