Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous Par...

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Bibliographic Details
Main Authors: Sohair M. Khojah, Anthony P. Payne, Dagmara McGuinness, Paul G. Shiels
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Cells
Subjects:
AS/AGU rat
sirtuins
p16Ink4a
SA-β-Gal
senescence
brain
Parkinson’s disease
Online Access:http://www.mdpi.com/2073-4409/5/4/38

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