Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment
This study aimed to investigate the ability of brown <i>Agaricus bisporus</i> extracts to enhance xerosis treatment via their biological activities, including their antioxidant, anti-aging, and anti-inflammation. Brown <i>A. bisporus</i> ethanol extract (EE) and brown <i&g...
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MDPI AG
2022-10-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/90/4/59 |
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| author | Nichcha Nitthikan Pimporn Leelapornpisid Ornchuma Naksuriya Nutjeera Intasai Kanokwan Kiattisin |
| author_facet | Nichcha Nitthikan Pimporn Leelapornpisid Ornchuma Naksuriya Nutjeera Intasai Kanokwan Kiattisin |
| author_sort | Nichcha Nitthikan |
| collection | DOAJ |
| description | This study aimed to investigate the ability of brown <i>Agaricus bisporus</i> extracts to enhance xerosis treatment via their biological activities, including their antioxidant, anti-aging, and anti-inflammation. Brown <i>A. bisporus</i> ethanol extract (EE) and brown <i>A. bisporus</i> water extract (WE) contained ergothioneine and gallic acid as their major compounds, as detected by HPLC, respectively. The WE exhibited the highest total polysaccharide content (734.04 ± 0.03 mg glucose/g extract) and total phenolic content (190.90 ± 0.07 mg gallic acid/g extract). The WE exhibited an inhibitory effect of 83.34 ± 18.66% on a collagenase enzyme, whereas the EE inhibited the elastase enzymes by 81.26 ± 4.37%. In addition, the EE also demonstrated strong activities against DPPH, with an IC<sub>50</sub> 0.30 ± 0.04 mg/mL, ABTS with a TEAC value of 8.06 ± 0.08 µM Trolox/g extract, and a FRAP assay with a FRAP value of 390.50 ± 0.32 mM FeSO<sub>4</sub>/g. In addition, all extracts were non-cytotoxic and could decrease the secretion of IL-6 and TNF-α in HaCaT cells. Therefore, brown <i>A. bisporus</i> extracts might be a potential natural raw material that can be further used in cosmeceutical products for xerosis treatment due to their good efficacy. |
| first_indexed | 2024-03-09T15:53:18Z |
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| id | doaj.art-249628800f4d44728b6f728fce72b5d7 |
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| issn | 0036-8709 2218-0532 |
| language | English |
| last_indexed | 2024-03-09T15:53:18Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-249628800f4d44728b6f728fce72b5d72023-11-24T17:51:25ZengMDPI AGScientia Pharmaceutica0036-87092218-05322022-10-019045910.3390/scipharm90040059Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis TreatmentNichcha Nitthikan0Pimporn Leelapornpisid1Ornchuma Naksuriya2Nutjeera Intasai3Kanokwan Kiattisin4PhD Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDivision of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandThis study aimed to investigate the ability of brown <i>Agaricus bisporus</i> extracts to enhance xerosis treatment via their biological activities, including their antioxidant, anti-aging, and anti-inflammation. Brown <i>A. bisporus</i> ethanol extract (EE) and brown <i>A. bisporus</i> water extract (WE) contained ergothioneine and gallic acid as their major compounds, as detected by HPLC, respectively. The WE exhibited the highest total polysaccharide content (734.04 ± 0.03 mg glucose/g extract) and total phenolic content (190.90 ± 0.07 mg gallic acid/g extract). The WE exhibited an inhibitory effect of 83.34 ± 18.66% on a collagenase enzyme, whereas the EE inhibited the elastase enzymes by 81.26 ± 4.37%. In addition, the EE also demonstrated strong activities against DPPH, with an IC<sub>50</sub> 0.30 ± 0.04 mg/mL, ABTS with a TEAC value of 8.06 ± 0.08 µM Trolox/g extract, and a FRAP assay with a FRAP value of 390.50 ± 0.32 mM FeSO<sub>4</sub>/g. In addition, all extracts were non-cytotoxic and could decrease the secretion of IL-6 and TNF-α in HaCaT cells. Therefore, brown <i>A. bisporus</i> extracts might be a potential natural raw material that can be further used in cosmeceutical products for xerosis treatment due to their good efficacy.https://www.mdpi.com/2218-0532/90/4/59brown <i>Agaricus bisporus</i>xerosisanti-inflammationanti-agingskin barrier function |
| spellingShingle | Nichcha Nitthikan Pimporn Leelapornpisid Ornchuma Naksuriya Nutjeera Intasai Kanokwan Kiattisin Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment Scientia Pharmaceutica brown <i>Agaricus bisporus</i> xerosis anti-inflammation anti-aging skin barrier function |
| title | Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment |
| title_full | Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment |
| title_fullStr | Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment |
| title_full_unstemmed | Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment |
| title_short | Potential and Alternative Bioactive Compounds from Brown <i>Agaricus bisporus</i> Mushroom Extracts for Xerosis Treatment |
| title_sort | potential and alternative bioactive compounds from brown i agaricus bisporus i mushroom extracts for xerosis treatment |
| topic | brown <i>Agaricus bisporus</i> xerosis anti-inflammation anti-aging skin barrier function |
| url | https://www.mdpi.com/2218-0532/90/4/59 |
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