Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease
Patients with Parkinson's disease (PD) frequently suffer from visual misperceptions and hallucinations, which are difficult to objectify and quantify. We aimed to develop an image recognition task to objectify misperceptions and to assess performance fluctuations in PD patients with and without...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219304231 |
| _version_ | 1811203603729219584 |
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| author | Kristina Miloserdov Carsten Schmidt-Samoa Kathleen Williams Christiane Anne Weinrich Igor Kagan Katrin Bürk Claudia Trenkwalder Mathias Bähr Melanie Wilke |
| author_facet | Kristina Miloserdov Carsten Schmidt-Samoa Kathleen Williams Christiane Anne Weinrich Igor Kagan Katrin Bürk Claudia Trenkwalder Mathias Bähr Melanie Wilke |
| author_sort | Kristina Miloserdov |
| collection | DOAJ |
| description | Patients with Parkinson's disease (PD) frequently suffer from visual misperceptions and hallucinations, which are difficult to objectify and quantify. We aimed to develop an image recognition task to objectify misperceptions and to assess performance fluctuations in PD patients with and without self-reported hallucinations. Thirty-two non-demented patients with Parkinson's disease (16 with and 16 without self-reported visual hallucinations) and 25 age-matched healthy controls (HC) were tested. Participants performed a dynamic image recognition task with real and scrambled images. We assessed misperception scores and intra-individual variability in recognition times. To gain insight into possible neural mechanisms related to misperceptions and performance fluctuations we correlated resting state network connectivity to the behavioral outcomes in a subsample of Parkinson's disease patients (N = 16). We found that PD patients with self-reported hallucinations (PD-VH) exhibited higher perceptual error rates, due to decreased perceptual sensitivity and not due to changed decision criteria. In addition, PD-VH patients exhibited higher intra-individual variability in recognition times than HC or PD-nonVH patients. Both, misperceptions and intra-individual variability were negatively correlated with resting state functional connectivity involving frontal and parietal brain regions, albeit in partly different subregions. Consistent with previous research suggesting that hallucinations arise from dysfunction in attentional networks, misperception scores correlated with reduced functional connectivity between the dorsal attention and salience network. Intra-individual variability correlated with decreased connectivity between somatomotor and right fronto-parietal networks. We conclude that our task can detect visual misperceptions that are more prevalent in PD-VH patients. In addition, fluctuating visual performance appear to be a signature of PD-VH patients, which might assist further studies of the underlying pathophysiological mechanisms and cognitive processes. Keywords: Parkinson's disease, Visual hallucinations, Misperceptions, Trial-by-trial variability, Continuous flash suppression |
| first_indexed | 2024-04-12T02:58:09Z |
| format | Article |
| id | doaj.art-24983527aa36452d86e4546b9f4c8a30 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T02:58:09Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-24983527aa36452d86e4546b9f4c8a302022-12-22T03:50:45ZengElsevierNeuroImage: Clinical2213-15822020-01-0125Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s diseaseKristina Miloserdov0Carsten Schmidt-Samoa1Kathleen Williams2Christiane Anne Weinrich3Igor Kagan4Katrin Bürk5Claudia Trenkwalder6Mathias Bähr7Melanie Wilke8Department of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany; German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Goettingen 37077, Germany; Leibniz Science Campus Primate Cognition, German Primate Center, Kellnerweg 4, Goettingen 37077, GermanyDepartment of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, GermanyDepartment of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, GermanyDepartment of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany; Department of Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, GermanyDepartment of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany; German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Goettingen 37077, Germany; Leibniz Science Campus Primate Cognition, German Primate Center, Kellnerweg 4, Goettingen 37077, GermanyKliniken Schmieder Stuttgart-Gerlingen, Solitudestraße 20, Gerlingen 70839, GermanyParacelsus-Elena Klinik, Klinikstraße 16, Kassel 34128, Germany; Department of Neurosurgery, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, GermanyDepartment of Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, GermanyDepartment of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany; German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Goettingen 37077, Germany; Leibniz Science Campus Primate Cognition, German Primate Center, Kellnerweg 4, Goettingen 37077, Germany; Corresponding author at: Department of Cognitive Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, Goettingen 37075, Germany.Patients with Parkinson's disease (PD) frequently suffer from visual misperceptions and hallucinations, which are difficult to objectify and quantify. We aimed to develop an image recognition task to objectify misperceptions and to assess performance fluctuations in PD patients with and without self-reported hallucinations. Thirty-two non-demented patients with Parkinson's disease (16 with and 16 without self-reported visual hallucinations) and 25 age-matched healthy controls (HC) were tested. Participants performed a dynamic image recognition task with real and scrambled images. We assessed misperception scores and intra-individual variability in recognition times. To gain insight into possible neural mechanisms related to misperceptions and performance fluctuations we correlated resting state network connectivity to the behavioral outcomes in a subsample of Parkinson's disease patients (N = 16). We found that PD patients with self-reported hallucinations (PD-VH) exhibited higher perceptual error rates, due to decreased perceptual sensitivity and not due to changed decision criteria. In addition, PD-VH patients exhibited higher intra-individual variability in recognition times than HC or PD-nonVH patients. Both, misperceptions and intra-individual variability were negatively correlated with resting state functional connectivity involving frontal and parietal brain regions, albeit in partly different subregions. Consistent with previous research suggesting that hallucinations arise from dysfunction in attentional networks, misperception scores correlated with reduced functional connectivity between the dorsal attention and salience network. Intra-individual variability correlated with decreased connectivity between somatomotor and right fronto-parietal networks. We conclude that our task can detect visual misperceptions that are more prevalent in PD-VH patients. In addition, fluctuating visual performance appear to be a signature of PD-VH patients, which might assist further studies of the underlying pathophysiological mechanisms and cognitive processes. Keywords: Parkinson's disease, Visual hallucinations, Misperceptions, Trial-by-trial variability, Continuous flash suppressionhttp://www.sciencedirect.com/science/article/pii/S2213158219304231 |
| spellingShingle | Kristina Miloserdov Carsten Schmidt-Samoa Kathleen Williams Christiane Anne Weinrich Igor Kagan Katrin Bürk Claudia Trenkwalder Mathias Bähr Melanie Wilke Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease NeuroImage: Clinical |
| title | Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease |
| title_full | Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease |
| title_fullStr | Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease |
| title_full_unstemmed | Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease |
| title_short | Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease |
| title_sort | aberrant functional connectivity of resting state networks related to misperceptions and intra individual variability in parkinson s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219304231 |
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