“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway
Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal transduction initiated by a wide range of membrane receptors. Among the proteins in this family JAK2 has been associated with important downstream proteins, including signal transducers and activators o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00287/full |
| _version_ | 1828847509197291520 |
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| author | Emira Bousoik Emira Bousoik Hamidreza Montazeri Aliabadi |
| author_facet | Emira Bousoik Emira Bousoik Hamidreza Montazeri Aliabadi |
| author_sort | Emira Bousoik |
| collection | DOAJ |
| description | Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal transduction initiated by a wide range of membrane receptors. Among the proteins in this family JAK2 has been associated with important downstream proteins, including signal transducers and activators of transcription (STATs), which in turn regulate the expression of a variety of proteins involved in induction or prevention of apoptosis. Therefore, the JAK/STAT signaling axis plays a major role in the proliferation and survival of different cancer cells, and may even be involved in resistance mechanisms against molecularly targeted drugs. Despite extensive research focused on the protein structure and mechanisms of activation of JAKs, and signal transduction through these proteins, their importance in cancer initiation and progression seem to be underestimated. This manuscript is an attempt to highlight the role of JAK proteins in cancer biology, the most recent developments in targeting JAKs, and the central role they play in intracellular cross-talks with other signaling cascades. |
| first_indexed | 2024-12-12T22:10:21Z |
| format | Article |
| id | doaj.art-2498ea0766784bac98d379930519d6da |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T22:10:21Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2498ea0766784bac98d379930519d6da2022-12-22T00:10:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-07-01810.3389/fonc.2018.00287406787“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling PathwayEmira Bousoik0Emira Bousoik1Hamidreza Montazeri Aliabadi2Department of Biomedical and Pharmaceutical Sciences, Center for Targeted Drug Delivery, School of Pharmacy, Chapman University, Irvine, CA, United StatesSchool of Pharmacy, Omar Al-Mukhtar University, Dèrna, LibyaDepartment of Biomedical and Pharmaceutical Sciences, Center for Targeted Drug Delivery, School of Pharmacy, Chapman University, Irvine, CA, United StatesJanus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal transduction initiated by a wide range of membrane receptors. Among the proteins in this family JAK2 has been associated with important downstream proteins, including signal transducers and activators of transcription (STATs), which in turn regulate the expression of a variety of proteins involved in induction or prevention of apoptosis. Therefore, the JAK/STAT signaling axis plays a major role in the proliferation and survival of different cancer cells, and may even be involved in resistance mechanisms against molecularly targeted drugs. Despite extensive research focused on the protein structure and mechanisms of activation of JAKs, and signal transduction through these proteins, their importance in cancer initiation and progression seem to be underestimated. This manuscript is an attempt to highlight the role of JAK proteins in cancer biology, the most recent developments in targeting JAKs, and the central role they play in intracellular cross-talks with other signaling cascades.https://www.frontiersin.org/article/10.3389/fonc.2018.00287/fulljanus tyrosine kinases (JAKs)signal transducers and activators of transcription (STATs)cancersignaling pathwaysproliferationsurvival |
| spellingShingle | Emira Bousoik Emira Bousoik Hamidreza Montazeri Aliabadi “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway Frontiers in Oncology janus tyrosine kinases (JAKs) signal transducers and activators of transcription (STATs) cancer signaling pathways proliferation survival |
| title | “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway |
| title_full | “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway |
| title_fullStr | “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway |
| title_full_unstemmed | “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway |
| title_short | “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway |
| title_sort | do we know jack about jak a closer look at jak stat signaling pathway |
| topic | janus tyrosine kinases (JAKs) signal transducers and activators of transcription (STATs) cancer signaling pathways proliferation survival |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00287/full |
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