Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响)
以雄性SD大鼠为实验动物，研究共轭亚油酸(CLA)和低氧的结合对肌肉脂质代谢的影响.取大鼠血液和肌肉，测葡萄糖、甘油三酯、组织乳酸、肌糖原、游离脂肪酸、胰岛素、脂肪酸合酶(FAS)、脂蛋白酯酶(LPL)、激素敏感酯酶(HSL).结果显示：CLA对大鼠体重没有显著影响(P>0. 05)，低氧降低大鼠体重(P<0. 01)；CLA可以升高胰岛素(P<0.01)，产生胰岛素抵抗，并升高游离脂肪酸(P<0.01)；CLA显著升高HSL(P<0. 01)，并降低LPL 和FAS(P<0. 01）；低氧显著降低HSL和FAS(P<0. 01），并升高LPL(P&l...
| Príomhchruthaitheoirí: | , , , |
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| Formáid: | Alt |
| Teanga: | zho |
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Zhejiang University Press
2014-03-01
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| Sraith: | Zhejiang Daxue xuebao. Lixue ban |
| Ábhair: | |
| Rochtain ar líne: | https://doi.org/10.3785/j.issn.1008-9497.2014.02.016 |
| _version_ | 1827303034767540224 |
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| author | ZHANGKai(张凯) ZHANGSha(张飒) LIBiao(黎标) CHENXuejun(陈雪君) |
| author_facet | ZHANGKai(张凯) ZHANGSha(张飒) LIBiao(黎标) CHENXuejun(陈雪君) |
| author_sort | ZHANGKai(张凯) |
| collection | DOAJ |
| description | 以雄性SD大鼠为实验动物，研究共轭亚油酸(CLA)和低氧的结合对肌肉脂质代谢的影响.取大鼠血液和肌肉，测葡萄糖、甘油三酯、组织乳酸、肌糖原、游离脂肪酸、胰岛素、脂肪酸合酶(FAS)、脂蛋白酯酶(LPL)、激素敏感酯酶(HSL).结果显示：CLA对大鼠体重没有显著影响(P>0. 05)，低氧降低大鼠体重(P<0. 01)；CLA可以升高胰岛素(P<0.01)，产生胰岛素抵抗，并升高游离脂肪酸(P<0.01)；CLA显著升高HSL(P<0. 01)，并降低LPL 和FAS(P<0. 01）；低氧显著降低HSL和FAS(P<0. 01），并升高LPL(P<0. 01).结论是CLA和低氧都能影响大鼠的生长；CLA对大鼠脂质代谢的影响有助于对低氧的适应，CLA和低氧都可以通过调节FAS、LPL、FAS影响肌肉脂质的代谢. |
| first_indexed | 2024-04-24T16:55:05Z |
| format | Article |
| id | doaj.art-249cc5539f3848a5915131f57a3db8fd |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T16:55:05Z |
| publishDate | 2014-03-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-249cc5539f3848a5915131f57a3db8fd2024-03-29T01:58:33ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972014-03-0141220320810.3785/j.issn.1008-9497.2014.02.016Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响)ZHANGKai(张凯)0ZHANGSha(张飒)1LIBiao(黎标)2CHENXuejun(陈雪君)3College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310018, China(杭州师范大学生命与环境科学学院，浙江 杭州 310018)College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310018, China(杭州师范大学生命与环境科学学院，浙江 杭州 310018)College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310018, China(杭州师范大学生命与环境科学学院，浙江 杭州 310018)College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310018, China(杭州师范大学生命与环境科学学院，浙江 杭州 310018)以雄性SD大鼠为实验动物，研究共轭亚油酸(CLA)和低氧的结合对肌肉脂质代谢的影响.取大鼠血液和肌肉，测葡萄糖、甘油三酯、组织乳酸、肌糖原、游离脂肪酸、胰岛素、脂肪酸合酶(FAS)、脂蛋白酯酶(LPL)、激素敏感酯酶(HSL).结果显示：CLA对大鼠体重没有显著影响(P>0. 05)，低氧降低大鼠体重(P<0. 01)；CLA可以升高胰岛素(P<0.01)，产生胰岛素抵抗，并升高游离脂肪酸(P<0.01)；CLA显著升高HSL(P<0. 01)，并降低LPL 和FAS(P<0. 01）；低氧显著降低HSL和FAS(P<0. 01），并升高LPL(P<0. 01).结论是CLA和低氧都能影响大鼠的生长；CLA对大鼠脂质代谢的影响有助于对低氧的适应，CLA和低氧都可以通过调节FAS、LPL、FAS影响肌肉脂质的代谢.https://doi.org/10.3785/j.issn.1008-9497.2014.02.016共轭亚油酸(cla)低氧葡萄糖脂肪代谢大鼠 |
| spellingShingle | ZHANGKai(张凯) ZHANGSha(张飒) LIBiao(黎标) CHENXuejun(陈雪君) Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) Zhejiang Daxue xuebao. Lixue ban 共轭亚油酸(cla) 低氧 葡萄糖 脂肪代谢 大鼠 |
| title | Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) |
| title_full | Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) |
| title_fullStr | Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) |
| title_full_unstemmed | Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) |
| title_short | Effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats(共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响) |
| title_sort | effects of conjugated linoleic acid and hypoxia on lipid metabolism of skeletal muscle in rats 共轭亚油酸和低氧对大鼠肌肉脂质代谢的影响 |
| topic | 共轭亚油酸(cla) 低氧 葡萄糖 脂肪代谢 大鼠 |
| url | https://doi.org/10.3785/j.issn.1008-9497.2014.02.016 |
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