SLEEP AND OLFACTORY CORTICAL PLASTICITY
In many systems, sleep plays a vital role in memory consolidation and synaptic homeostasis. These processes together help store information of biological significance and reset synaptic circuits to facilitate acquisition of information in the future. In this review, we describe recent evidence of...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00134/full |
| _version_ | 1811237070099709952 |
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| author | Dylan eBarnes Donald A Wilson Donald A Wilson |
| author_facet | Dylan eBarnes Donald A Wilson Donald A Wilson |
| author_sort | Dylan eBarnes |
| collection | DOAJ |
| description | In many systems, sleep plays a vital role in memory consolidation and synaptic homeostasis. These processes together help store information of biological significance and reset synaptic circuits to facilitate acquisition of information in the future. In this review, we describe recent evidence of sleep-dependent changes in olfactory system structure and function which contribute to odor memory and perception. During slow-wave sleep, the piriform cortex becomes hypo-responsive to odor stimulation and instead displays sharp-wave activity similar to that observed within the hippocampal formation. Furthermore, the functional connectivity between the piriform cortex and other cortical and limbic regions is enhanced during slow-wave sleep compared to waking. This combination of conditions may allow odor memory consolidation to occur during a state of reduced external interference and facilitate association of odor memories with stored hedonic and contextual cues. Evidence consistent with sleep-dependent odor replay within olfactory cortical circuits is presented. These data suggest that both the strength and precision of odor memories is sleep-dependent. The work further emphasizes the critical role of synaptic plasticity and memory in not only odor memory but also basic odor perception. The work also suggests a possible link between sleep disturbances that are frequently co-morbid with a wide range of pathologies including Alzheimer’s disease, schizophrenia and depression and the known olfactory impairments associated with those disorders. |
| first_indexed | 2024-04-12T12:18:35Z |
| format | Article |
| id | doaj.art-249d31e39a0342acbcbd695192c6727f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T12:18:35Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-249d31e39a0342acbcbd695192c6727f2022-12-22T03:33:21ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-04-01810.3389/fnbeh.2014.0013489323SLEEP AND OLFACTORY CORTICAL PLASTICITYDylan eBarnes0Donald A Wilson1Donald A Wilson2Nathan Kline Institute for Psychiatric ResearchNathan Kline Institute for Psychiatric ResearchNew York University Langone School of MedicineIn many systems, sleep plays a vital role in memory consolidation and synaptic homeostasis. These processes together help store information of biological significance and reset synaptic circuits to facilitate acquisition of information in the future. In this review, we describe recent evidence of sleep-dependent changes in olfactory system structure and function which contribute to odor memory and perception. During slow-wave sleep, the piriform cortex becomes hypo-responsive to odor stimulation and instead displays sharp-wave activity similar to that observed within the hippocampal formation. Furthermore, the functional connectivity between the piriform cortex and other cortical and limbic regions is enhanced during slow-wave sleep compared to waking. This combination of conditions may allow odor memory consolidation to occur during a state of reduced external interference and facilitate association of odor memories with stored hedonic and contextual cues. Evidence consistent with sleep-dependent odor replay within olfactory cortical circuits is presented. These data suggest that both the strength and precision of odor memories is sleep-dependent. The work further emphasizes the critical role of synaptic plasticity and memory in not only odor memory but also basic odor perception. The work also suggests a possible link between sleep disturbances that are frequently co-morbid with a wide range of pathologies including Alzheimer’s disease, schizophrenia and depression and the known olfactory impairments associated with those disorders.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00134/fullmemory consolidationOlfactionpiriform cortexodor perceptionslow-wave sleepOdor memory |
| spellingShingle | Dylan eBarnes Donald A Wilson Donald A Wilson SLEEP AND OLFACTORY CORTICAL PLASTICITY Frontiers in Behavioral Neuroscience memory consolidation Olfaction piriform cortex odor perception slow-wave sleep Odor memory |
| title | SLEEP AND OLFACTORY CORTICAL PLASTICITY |
| title_full | SLEEP AND OLFACTORY CORTICAL PLASTICITY |
| title_fullStr | SLEEP AND OLFACTORY CORTICAL PLASTICITY |
| title_full_unstemmed | SLEEP AND OLFACTORY CORTICAL PLASTICITY |
| title_short | SLEEP AND OLFACTORY CORTICAL PLASTICITY |
| title_sort | sleep and olfactory cortical plasticity |
| topic | memory consolidation Olfaction piriform cortex odor perception slow-wave sleep Odor memory |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00134/full |
| work_keys_str_mv | AT dylanebarnes sleepandolfactorycorticalplasticity AT donaldawilson sleepandolfactorycorticalplasticity AT donaldawilson sleepandolfactorycorticalplasticity |