Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors
Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-02-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0815 |
| _version_ | 1811158359300112384 |
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| author | CUI Xue WENG Yiming WANG Peiwei PENG Min |
| author_facet | CUI Xue WENG Yiming WANG Peiwei PENG Min |
| author_sort | CUI Xue |
| collection | DOAJ |
| description | Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression of PD1-TCF1+CD8+T cells was detected through quantitative analysis by multiplex immunofluorescence. Survival curves were described by the Kaplan-Meier method. Pearson's correlation test was used for correlation analysis. Results The high levels of PD1-TCF1+CD8+T cells had a better PFS in NSCLC and ESCC cohorts. In the NSCLC cohort, high levels of PD1-TCF1+CD8+ T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1+CD8+ stem-like memory T cell expression indicates improved prognosis and immune response and is associated with the formation of TLSs in the tumor microenvironment of NSCLC. |
| first_indexed | 2024-04-10T05:23:17Z |
| format | Article |
| id | doaj.art-249d415e3add4ee2af3abe2d6de86119 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-10T05:23:17Z |
| publishDate | 2023-02-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-249d415e3add4ee2af3abe2d6de861192023-03-08T05:14:03ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-02-0150214615010.3971/j.issn.1000-8578.2023.22.08158578.2023.22.0815Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in TumorsCUI Xue0WENG Yiming1WANG Peiwei2PENG Min3Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaObjective To investigate the impact of PD1-TCF1+CD8+ stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression of PD1-TCF1+CD8+T cells was detected through quantitative analysis by multiplex immunofluorescence. Survival curves were described by the Kaplan-Meier method. Pearson's correlation test was used for correlation analysis. Results The high levels of PD1-TCF1+CD8+T cells had a better PFS in NSCLC and ESCC cohorts. In the NSCLC cohort, high levels of PD1-TCF1+CD8+ T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1+CD8+ stem-like memory T cell expression indicates improved prognosis and immune response and is associated with the formation of TLSs in the tumor microenvironment of NSCLC.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0815tumor microenvironmentprognosistertiary lymphoid structuresstem cell-like memory t cell |
| spellingShingle | CUI Xue WENG Yiming WANG Peiwei PENG Min Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors Zhongliu Fangzhi Yanjiu tumor microenvironment prognosis tertiary lymphoid structures stem cell-like memory t cell |
| title | Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors |
| title_full | Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors |
| title_fullStr | Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors |
| title_full_unstemmed | Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors |
| title_short | Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors |
| title_sort | effect of pd1 tcf1 cd8 stem like memory t cells on immunotherapy prognosis and tertiary lymphoid structures in tumors |
| topic | tumor microenvironment prognosis tertiary lymphoid structures stem cell-like memory t cell |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0815 |
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