Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity
Abstract There has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classif...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11455-7 |
| _version_ | 1828202659301031936 |
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| author | Pei-Ying Chen Eugene Yu-Chuan Kang Kuan-Jen Chen Xiao Chun Ling Yin-Hsi Chang Nan-Kai Wang Laura Liu Yen-Po Chen Yih-Shiou Hwang Chi-Chun Lai Wei-Chi Wu |
| author_facet | Pei-Ying Chen Eugene Yu-Chuan Kang Kuan-Jen Chen Xiao Chun Ling Yin-Hsi Chang Nan-Kai Wang Laura Liu Yen-Po Chen Yih-Shiou Hwang Chi-Chun Lai Wei-Chi Wu |
| author_sort | Pei-Ying Chen |
| collection | DOAJ |
| description | Abstract There has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classified into five groups: patients with stage 1 and 2 FEVR (FEVR group), patients with ROP who received treatment (treated ROP group), patients with ROP who did not receive treatment (untreated ROP group), patients without ROP who had been born preterm (preterm group), and healthy patients who had been born at term (full-term group). Visual acuity, refractive error, characteristics of the optical components, and features of the fovea were compared. In total, 179 eyes from 100 patients were included. Patients in the FEVR group had the highest degrees of myopia (p < 0.001). The axial length of patients in the FEVR group was significantly longer than that of patients in the treated and untreated ROP, preterm, and full-term groups (p < 0.001, p < 0.001, p = 0.001, and p = 0.003, respectively). Patients in the FEVR group had a higher proportion of grade 4 foveal hypoplasia and thinner foveae than those in the other groups (p < 0.001). Patients with FEVR had significantly greater myopic change than patients with ROP; the significantly longer axial length of the FEVR group might be the reason for the greater myopic change and lesser macular thickness. Patients in the FEVR group had more foveal hypoplasia than those in the other groups. |
| first_indexed | 2024-04-12T11:51:18Z |
| format | Article |
| id | doaj.art-249d7a078f01482cb5cf6ab4afd0289a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T11:51:18Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-249d7a078f01482cb5cf6ab4afd0289a2022-12-22T03:34:09ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-11455-7Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurityPei-Ying Chen0Eugene Yu-Chuan Kang1Kuan-Jen Chen2Xiao Chun Ling3Yin-Hsi Chang4Nan-Kai Wang5Laura Liu6Yen-Po Chen7Yih-Shiou Hwang8Chi-Chun Lai9Wei-Chi Wu10Department of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia UniversityDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalCollege of Medicine, Chang Gung UniversityDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalDepartment of Ophthalmology, Linkou Chang Gung Memorial HospitalAbstract There has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classified into five groups: patients with stage 1 and 2 FEVR (FEVR group), patients with ROP who received treatment (treated ROP group), patients with ROP who did not receive treatment (untreated ROP group), patients without ROP who had been born preterm (preterm group), and healthy patients who had been born at term (full-term group). Visual acuity, refractive error, characteristics of the optical components, and features of the fovea were compared. In total, 179 eyes from 100 patients were included. Patients in the FEVR group had the highest degrees of myopia (p < 0.001). The axial length of patients in the FEVR group was significantly longer than that of patients in the treated and untreated ROP, preterm, and full-term groups (p < 0.001, p < 0.001, p = 0.001, and p = 0.003, respectively). Patients in the FEVR group had a higher proportion of grade 4 foveal hypoplasia and thinner foveae than those in the other groups (p < 0.001). Patients with FEVR had significantly greater myopic change than patients with ROP; the significantly longer axial length of the FEVR group might be the reason for the greater myopic change and lesser macular thickness. Patients in the FEVR group had more foveal hypoplasia than those in the other groups.https://doi.org/10.1038/s41598-022-11455-7 |
| spellingShingle | Pei-Ying Chen Eugene Yu-Chuan Kang Kuan-Jen Chen Xiao Chun Ling Yin-Hsi Chang Nan-Kai Wang Laura Liu Yen-Po Chen Yih-Shiou Hwang Chi-Chun Lai Wei-Chi Wu Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity Scientific Reports |
| title | Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| title_full | Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| title_fullStr | Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| title_full_unstemmed | Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| title_short | Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| title_sort | foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity |
| url | https://doi.org/10.1038/s41598-022-11455-7 |
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