Synthetic Sulfated Polymers Control Amyloid Aggregation of Ovine Prion Protein and Decrease Its Toxicity

Synthetic Sulfated Polymers Control Amyloid Aggregation of Ovine Prion Protein and Decrease Its Toxicity

Amyloid aggregation, including aggregation and propagation of prion protein, is a key factor in numerous human diseases, so-called amyloidosis, with a very poor ability for treatment or prevention. The present work describes the effect of sulfated or sulfonated polymers (sodium dextran sulfate, poly...

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Bibliographic Details
Main Authors: Pavel Semenyuk, Diana Evstafyeva, Vladimir Izumrudov, Vladimir Muronetz
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Polymers
Subjects:
prion protein
amyloid
polyanion
amyloidosis
artificial chaperone
polystyrene sulfonate
Online Access:https://www.mdpi.com/2073-4360/14/7/1478

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