Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients
Abstract Background Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the associations between NPS with AD pathologic biomarkers and cerebral small v...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-024-01434-7 |
| _version_ | 1827291695992012800 |
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| author | Qingze Zeng Yanbo Wang Shuyue Wang Xiao Luo Kaicheng Li Xiaopei Xu Xiaocao Liu Luwei Hong Jixuan Li Zheyu Li Xinyi Zhang Siyan Zhong Zhirong Liu Peiyu Huang Yanxing Chen Minming Zhang for behalf of Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Qingze Zeng Yanbo Wang Shuyue Wang Xiao Luo Kaicheng Li Xiaopei Xu Xiaocao Liu Luwei Hong Jixuan Li Zheyu Li Xinyi Zhang Siyan Zhong Zhirong Liu Peiyu Huang Yanxing Chen Minming Zhang for behalf of Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Qingze Zeng |
| collection | DOAJ |
| description | Abstract Background Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the associations between NPS with AD pathologic biomarkers and cerebral small vessel disease (SVD), but it remains unknown whether AD pathology and SVD contribute to different sub-syndromes independently or aggravate same symptoms synergistically. Method We included 445 cognitively impaired individuals (including 316 MCI and 129 AD) with neuropsychiatric, cerebrospinal fluid (CSF) biomarkers (Aβ42, p-tau, and t-tau) and multi-model MRI data. Psychiatric symptoms were accessed by using the Neuropsychiatric Inventory (NPI). Visual assessment of SVD (white matter hyperintensity, microbleed, perivascular space, lacune) on MRI images was performed by experienced radiologist. Linear regression analyses were conducted to test the association between neuropsychiatric symptoms with AD pathology and CSVD burden after adjustment for age, sex, education, apolipoprotein E (APOE) ε4 carrier status, and clinical diagnosis. Results The NPI total scores were related to microbleed (estimate 2.424; 95% CI [0.749, 4.099]; P =0.005). Considering the sub-syndromes, the hyperactivity was associated with microbleed (estimate 0.925; 95% CI [0.115, 1.735]; P =0.025), whereas the affective symptoms were correlated to CSF level of Aβ42 (estimate -0.006; 95% CI [-0.011, -0.002]; P =0.005). Furthermore, we found the apathy sub-syndrome was associated with CSF t-tau/Aβ42 (estimate 0.636; 95% CI [0.078, 1.194]; P =0.041) and microbleed (estimate 0.693; 95% CI [0.046, 1.340]; P =0.036). In addition, we found a significant interactive effect between CSF t-tau/Aβ42 and microbleed (estimate 0.993; 95% CI [0.360, 1.626]; P =0.019) on severity of apathy sub-syndrome. Conclusion Our study showed that CSF Aβ42 was associated with affective symptoms, but microbleed was correlated with hyperactivity and apathy, suggesting the effect of AD pathology and SVD on different neuropsychiatric sub-syndromes. |
| first_indexed | 2024-04-24T12:42:19Z |
| format | Article |
| id | doaj.art-24a63e60db4649d78448adb08ffe6919 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-24T12:42:19Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-24a63e60db4649d78448adb08ffe69192024-04-07T11:10:53ZengBMCAlzheimer’s Research & Therapy1758-91932024-04-0116111110.1186/s13195-024-01434-7Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patientsQingze Zeng0Yanbo Wang1Shuyue Wang2Xiao Luo3Kaicheng Li4Xiaopei Xu5Xiaocao Liu6Luwei Hong7Jixuan Li8Zheyu Li9Xinyi Zhang10Siyan Zhong11Zhirong Liu12Peiyu Huang13Yanxing Chen14Minming Zhang15for behalf of Alzheimer’s Disease Neuroimaging InitiativeDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Neurology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictDepartment of Radiology, Zhejiang University School of Medicine Second Affiliated Hospital, Shangcheng DistrictAbstract Background Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the associations between NPS with AD pathologic biomarkers and cerebral small vessel disease (SVD), but it remains unknown whether AD pathology and SVD contribute to different sub-syndromes independently or aggravate same symptoms synergistically. Method We included 445 cognitively impaired individuals (including 316 MCI and 129 AD) with neuropsychiatric, cerebrospinal fluid (CSF) biomarkers (Aβ42, p-tau, and t-tau) and multi-model MRI data. Psychiatric symptoms were accessed by using the Neuropsychiatric Inventory (NPI). Visual assessment of SVD (white matter hyperintensity, microbleed, perivascular space, lacune) on MRI images was performed by experienced radiologist. Linear regression analyses were conducted to test the association between neuropsychiatric symptoms with AD pathology and CSVD burden after adjustment for age, sex, education, apolipoprotein E (APOE) ε4 carrier status, and clinical diagnosis. Results The NPI total scores were related to microbleed (estimate 2.424; 95% CI [0.749, 4.099]; P =0.005). Considering the sub-syndromes, the hyperactivity was associated with microbleed (estimate 0.925; 95% CI [0.115, 1.735]; P =0.025), whereas the affective symptoms were correlated to CSF level of Aβ42 (estimate -0.006; 95% CI [-0.011, -0.002]; P =0.005). Furthermore, we found the apathy sub-syndrome was associated with CSF t-tau/Aβ42 (estimate 0.636; 95% CI [0.078, 1.194]; P =0.041) and microbleed (estimate 0.693; 95% CI [0.046, 1.340]; P =0.036). In addition, we found a significant interactive effect between CSF t-tau/Aβ42 and microbleed (estimate 0.993; 95% CI [0.360, 1.626]; P =0.019) on severity of apathy sub-syndrome. Conclusion Our study showed that CSF Aβ42 was associated with affective symptoms, but microbleed was correlated with hyperactivity and apathy, suggesting the effect of AD pathology and SVD on different neuropsychiatric sub-syndromes.https://doi.org/10.1186/s13195-024-01434-7Alzheimer’s diseaseNeuropsychiatryAmyloidSmall vessel diseaseBiomarkers |
| spellingShingle | Qingze Zeng Yanbo Wang Shuyue Wang Xiao Luo Kaicheng Li Xiaopei Xu Xiaocao Liu Luwei Hong Jixuan Li Zheyu Li Xinyi Zhang Siyan Zhong Zhirong Liu Peiyu Huang Yanxing Chen Minming Zhang for behalf of Alzheimer’s Disease Neuroimaging Initiative Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients Alzheimer’s Research & Therapy Alzheimer’s disease Neuropsychiatry Amyloid Small vessel disease Biomarkers |
| title | Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients |
| title_full | Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients |
| title_fullStr | Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients |
| title_full_unstemmed | Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients |
| title_short | Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients |
| title_sort | cerebrospinal fluid amyloid β and cerebral microbleed are associated with distinct neuropsychiatric sub syndromes in cognitively impaired patients |
| topic | Alzheimer’s disease Neuropsychiatry Amyloid Small vessel disease Biomarkers |
| url | https://doi.org/10.1186/s13195-024-01434-7 |
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