Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls?

Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls?

The AKT protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a therapeutic target, especially in hormone receptor-positive (HR) breast cancers, where the PI3K/AKT signaling pathway is...

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Bibliographic Details
Main Authors:	Benoîte Mery, Coralie Poulard, Muriel Le Romancer, Olivier Trédan
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Series:	International Journal of Molecular Sciences
Subjects:	estrogen-receptor-positive metastatic breast cancer endocrine resistance serine/threonine kinase (AKT) signaling pathway
Online Access:	https://www.mdpi.com/1422-0067/22/24/13512

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