Biphasic synovial sarcomas of the liver: a case report and literature review
Abstract Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases hav...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
|
| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-022-01233-4 |
| _version_ | 1828783296362840064 |
|---|---|
| author | Defeng Liang Lingyu Meng Shanshan Wang Dan Yi Yahui Liu |
| author_facet | Defeng Liang Lingyu Meng Shanshan Wang Dan Yi Yahui Liu |
| author_sort | Defeng Liang |
| collection | DOAJ |
| description | Abstract Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. Case presentation We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. Conclusion Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids. |
| first_indexed | 2024-12-11T18:02:43Z |
| format | Article |
| id | doaj.art-24a7a848a01d4e63ae8aca433091f43d |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-11T18:02:43Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-24a7a848a01d4e63ae8aca433091f43d2022-12-22T00:55:50ZengBMCDiagnostic Pathology1746-15962022-06-011711510.1186/s13000-022-01233-4Biphasic synovial sarcomas of the liver: a case report and literature reviewDefeng Liang0Lingyu Meng1Shanshan Wang2Dan Yi3Yahui Liu4Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin UniversityAbstract Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. Case presentation We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. Conclusion Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids.https://doi.org/10.1186/s13000-022-01233-4Synovial sarcomaLiverDiagnosisCase report |
| spellingShingle | Defeng Liang Lingyu Meng Shanshan Wang Dan Yi Yahui Liu Biphasic synovial sarcomas of the liver: a case report and literature review Diagnostic Pathology Synovial sarcoma Liver Diagnosis Case report |
| title | Biphasic synovial sarcomas of the liver: a case report and literature review |
| title_full | Biphasic synovial sarcomas of the liver: a case report and literature review |
| title_fullStr | Biphasic synovial sarcomas of the liver: a case report and literature review |
| title_full_unstemmed | Biphasic synovial sarcomas of the liver: a case report and literature review |
| title_short | Biphasic synovial sarcomas of the liver: a case report and literature review |
| title_sort | biphasic synovial sarcomas of the liver a case report and literature review |
| topic | Synovial sarcoma Liver Diagnosis Case report |
| url | https://doi.org/10.1186/s13000-022-01233-4 |
| work_keys_str_mv | AT defengliang biphasicsynovialsarcomasoftheliveracasereportandliteraturereview AT lingyumeng biphasicsynovialsarcomasoftheliveracasereportandliteraturereview AT shanshanwang biphasicsynovialsarcomasoftheliveracasereportandliteraturereview AT danyi biphasicsynovialsarcomasoftheliveracasereportandliteraturereview AT yahuiliu biphasicsynovialsarcomasoftheliveracasereportandliteraturereview |